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  1. The aim of this analysis was to examine long-term effects of changes in metabolic status on microvascular endothelial function and cardiovascular diseases (CVD) biomarkers among physically active middle-aged men.

    Authors: Magdalena Kwaśniewska, Joanna Kozińska, Elżbieta Dziankowska-Zaborszczyk, Tomasz Kostka, Anna Jegier, Ewa Rębowska, Milena Orczykowska, Joanna Leszczyńska and Wojciech Drygas
    Citation: Diabetology & Metabolic Syndrome 2015 7:81
    Content type: Research Published on:

  2. High prevalence of metabolic diseases among young professional athletes with large body sizes has raised growing attention. However, few studies specifically examined whether additional aerobic exercise provid...

    Authors: Jianjun Guo, Yanmei Lou, Xi Zhang and Yiqing Song
    Citation: Diabetology & Metabolic Syndrome 2015 7:78
    Content type: Research Published on:

  3. Although the population-based German disease management programs (DMPs) for diabetes mellitus (DM) and coronary heart disease (CHD) are among the biggest worldwide, evidence on the effectiveness of these progr...

    Authors: Michael Laxy, Renée Stark, Christa Meisinger, Inge Kirchberger, Margit Heier, Wolfgang von Scheidt and Rolf Holle
    Citation: Diabetology & Metabolic Syndrome 2015 7:77
    Content type: Research Published on:

  4. An improved understanding of the vascular function, measured in non-invasive way, in constantly growing group of patients at increased risk of cardiovascular events is necessary. To evaluate the effects of met...

    Authors: Justyna Domienik-Karłowicz, Wojciech Lisik, Zuzanna Rymarczyk, Olga Dzikowska-Diduch, Andrzej Chmura, Urszula Demkow and Piotr Pruszczyk
    Citation: Diabetology & Metabolic Syndrome 2015 7:76
    Content type: Research Published on:

  5. Gut microbiota is now known to control glucose metabolism. Previous studies have shown that probiotics and prebiotics may improve glucose metabolism, but their effects have not been studied in combination with...

    Authors: Lotta K. Stenman, Aurélie Waget, Céline Garret, François Briand, Rémy Burcelin, Thierry Sulpice and Sampo Lahtinen
    Citation: Diabetology & Metabolic Syndrome 2015 7:75
    Content type: Research Published on:

  6. This study aimed to estimate the performance of diabetic cardiovascular autonomic neuropathy (DCAN) diagnostic tests in the absence of a gold standard.

    Authors: Jun Chen, Shuang-Bin Yang, Juanmei Liu and Zi-Hui Tang
    Citation: Diabetology & Metabolic Syndrome 2015 7:74
    Content type: Research Published on:

    The Erratum to this article has been published in Diabetology & Metabolic Syndrome 2017 9:14

  7. A novel obesity classification method has been proposed using body mass index (BMI) and waist–height ratio (WHtR) together. However, the utility of this approach is unclear. In this study we compare the metabo...

    Authors: Seán R. Millar, Ivan J. Perry and Catherine M. Phillips
    Citation: Diabetology & Metabolic Syndrome 2015 7:73
    Content type: Research Published on:

  8. Type 2 diabetes is commonly characterized by insulin deficiency and decreased sensitivity of insulin receptors, leading to a chronic state of hyperglycemia in individuals. Disease progression induces changes i...

    Authors: Bradley T. Gao, Ryan P. Lee, Youde Jiang, Jena J. Steinle and Vanessa M. Morales-Tirado
    Citation: Diabetology & Metabolic Syndrome 2015 7:72
    Content type: Research Published on:

  9. The emerging role of TLR2/4 as immuno-metabolic receptors points to key involvement of TLR/IL-1R/MyD88 pathway in obesity/type-2 diabetes (T2D). IL1R-associated kinase (IRAK)-1 is a critical adapter protein (s...

    Authors: Rasheed Ahmad, Puthiyaveetil Kochumon Shihab, Reeby Thomas, Munera Alghanim, Amal Hasan, Sardar Sindhu and Kazem Behbehani
    Citation: Diabetology & Metabolic Syndrome 2015 7:71
    Content type: Research Published on:

  10. Vildagliptin, a DPP-4 inhibitor widely used for the treatment of type 2 diabetes mellitus (T2DM), shows beneficial effects on endothelial function. This study aims to evaluate the effect of vildagliptin on end...

    Authors: Luciana Neves Cosenso-Martin, Luiz Tadeu Giollo-Júnior, Débora Dada Martineli, Cláudia Bernardi Cesarino, Marcelo Arruda Nakazone, José Paulo Cipullo and José Fernando Vilela-Martin
    Citation: Diabetology & Metabolic Syndrome 2015 7:70
    Content type: Research Published on:

  11. Gastric bypass surgery seems to have an effect on glucose metabolism beyond what is mediated through weight reduction. The magnitude of this effect on fasting and post-challenge glucose levels remains unknown.

    Authors: Dag Hofsø, Kåre I. Birkeland, Jens J. Holst, Jens Bollerslev, Rune Sandbu, Jo Røislien and Jøran Hjelmesæth
    Citation: Diabetology & Metabolic Syndrome 2015 7:69
    Content type: Short report Published on:

  12. Obesity is a risk factor for cardiovascular disease, but metabolic disturbances can also lead to the development of this disease. Therefore, we investigated the associations between obesity subtype, considerin...

    Authors: Ha-Na Kim, Se-Hong Kim, Young-Mi Eun and Sang-Wook Song
    Citation: Diabetology & Metabolic Syndrome 2015 7:68
    Content type: Research Published on:

  13. To maintain euglycemia in healthy organisms, hepatic glucose production is increased during fasting and decreased during the postprandial period. This whole process is supported by insulin levels. These respon...

    Authors: Rodolfo Marinho, Rania A. Mekary, Vitor Rosetto Muñoz, Ricardo José Gomes, José Rodrigo Pauli and Leandro Pereira de Moura
    Citation: Diabetology & Metabolic Syndrome 2015 7:67
    Content type: Review Published on:

  14. Diabetes treatment requires specialized multi-professional teams, supplies for blood glucose monitoring and training for self-injections of human insulin or insulin analogues. The State Health Secretariat of t...

    Authors: Eliziane Brandão Leite, Hermelinda Cordeiro Pedrosa and Luiz Augusto Casulari
    Citation: Diabetology & Metabolic Syndrome 2015 7:66
    Content type: Research Published on:

  15. To determine whether cortisol secretion and glucocorticoid receptors in lymphocytes and monocytes are altered in patients with impaired glucose tolerance, and whether treatment with a hypocaloric diet and metf...

    Authors: Luiz Augusto Casulari, Donatella Dondi, Fabio Celotti, Fábio Vinicius Pires da Silva, Caio Eduardo Gonçalves Reis and Teresa Helena Macedo da Costa
    Citation: Diabetology & Metabolic Syndrome 2015 7:65
    Content type: Research Published on:

  16. Pentoxifylline is a methylxanthine derivative with significant anti-inflammatory, anti-fibrotic, and anti-proliferative properties. Studies have shown that pentoxifylline may have renoprotective effects in pat...

    Authors: Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Seung Soo Sheen, Choon Hee Chung, Chul Woo Ahn, Se Hwa Kim, Yong-Wook Cho, Seok Won Park, Soo-Kyung Kim, Chul Sik Kim, Kyung Wook Kim and Kwan Woo Lee
    Citation: Diabetology & Metabolic Syndrome 2015 7:64
    Content type: Research Published on:

  17. Type 2 diabetes mellitus is a serious, chronic, progressive and widespread disease. Metformin is the most commonly prescribed initial therapy, but combination with other antidiabetic agents usually becomes nec...

    Authors: Elena Pavlova Filipova, Katya Hristova Uzunova and Toni Yonkov Vekov
    Citation: Diabetology & Metabolic Syndrome 2015 7:63
    Content type: Review Published on:

  18. Diabetes is closely linked with coronary artery disease, either by means of direct effects of hyperglycemia, or indirectly by its frequent association with dyslipidemia. Any treatment for diabetes that has bey...

    Authors: Marcelo R. Nasser Hissa, Lilian Loureiro Albuquerque Cavalcante, Sergio Botelho Guimarães and Miguel Nasser Hissa
    Citation: Diabetology & Metabolic Syndrome 2015 7:62
    Content type: Research Published on:

  20. Depression and diabetes have been recognized as major public health issues in China, however, no studies to date examined the factors associated with the development of depression in patients with diabetes in ...

    Authors: Weijun Zhang, Huiwen Xu, Shuliang Zhao, Shinan Yin, Xiaohua Wang, Jing Guo, Shengfa Zhang, Huixuan Zhou, Fugang Wang, Linni Gu, Lei Zhu, Haibo Yu, Zhiyong Qu and Donghua Tian
    Citation: Diabetology & Metabolic Syndrome 2015 7:60
    Content type: Research Published on:

  21. Insulin resistance (IR) reduces reactivity of the target organ to blood insulin. Researchers have attempted to evaluate IR using various serum lipid concentration ratios. We aimed to determine the most strongl...

    Authors: A Ri Byun, Sang Wha Lee, Hong Soo Lee and Kyung Won Shim
    Citation: Diabetology & Metabolic Syndrome 2015 7:59
    Content type: Research Published on:

  22. Many studies evaluated the best predictors for cardiovascular disease (CVD) events in individuals with type 2 diabetes (T2D), but few studies examined the factors most strongly associated with mortality in T2D...

    Authors: Laura M. Raffield, Fang-Chi Hsu, Amanda J. Cox, J. Jeffrey Carr, Barry I. Freedman and Donald W. Bowden
    Citation: Diabetology & Metabolic Syndrome 2015 7:58
    Content type: Research Published on:

  23. The development of extended-action insulin analogues was motivated by the unfavorable pharmacokinetic (PK) profile of the conventional long-acting insulin formulations, generally associated with marked inter a...

    Authors: Marcos Antonio Tambascia and Freddy Goldberg Eliaschewitz
    Citation: Diabetology & Metabolic Syndrome 2015 7:57
    Content type: Review Published on:

  24. We examined the feasibility and efficacy of using a non-mydriatic camera to screen for diabetic retinopathy (DR) among youth with type 1 or type 2 diabetes seen in a pediatric endocrinology clinic serving Alab...

    Authors: Jeffrey L. Tapley, Gerald McGwin Jr., Ambika P. Ashraf, Paul A. MacLennan, Koula Callahan, Karen Searcey, C. Douglas Witherspoon, Jinan Saaddine and Cynthia Owsley
    Citation: Diabetology & Metabolic Syndrome 2015 7:56
    Content type: Research Published on:

  25. Type 2 diabetes (T2D) is very prevalent among the elderly. Insulin therapy is often required for glycemic control. The association of starting this therapy with depressive symptoms as well the health-related q...

    Authors: R. A. Oliveira, M. Tostes, V. A. Queiroz, M. Rodacki and L. Zajdenverg
    Citation: Diabetology & Metabolic Syndrome 2015 7:55
    Content type: Short report Published on:

  26. The initial discovery of resistin and resistin-like molecules (RELMs) in rodents suggested a role for these adipocytokines in molecular linkage of obesity, Type 2 Diabetes mellitus and metabolic syndrome. Sinc...

    Authors: Fatima Al Hannan and Kevin Gerard Culligan
    Citation: Diabetology & Metabolic Syndrome 2015 7:54
    Content type: Review Published on:

  27. Low levels of vitamin D have been related to increased mortality and morbidity in several non-diabetic studies. We aimed to prospectively study relationships between serum 25-OH vitamin D3 (vitamin D) and of seru...

    Authors: Pär Jennersjö, Hans Guldbrand, Stefan Björne, Toste Länne, Mats Fredrikson, Torbjörn Lindström, Magnus Wijkman, Carl Johan Östgren and Fredrik H. Nystrom
    Citation: Diabetology & Metabolic Syndrome 2015 7:53
    Content type: Research Published on:

  28. A dysregulation in the metabolism of lipids may be an early marker of autoimmunity in Type 1 Diabetes (T1D). It would be of general importance to identify metabolic patterns that would predict the risk for T1D...

    Authors: D.B. Araujo de Pina Cabral, J.R. Dantas, H. Skärstrand, B. Barone, F. Carvalho, R. Tortora, A. Milech, F. Vaziri-Sani, J.E. P. Oliveira, L. Zajdenverg and M. Rodacki
    Citation: Diabetology & Metabolic Syndrome 2015 7:52
    Content type: Short report Published on:

  29. Peripheral Diabetic Neuropathy (PDN) and cognitive impairment are complications of Diabetes Mellitus (DM) that seem to share several underlying mechanisms. The aim of this study was to investigate whether diab...

    Authors: Rodrigo O. Moreira, Ana Luiza Soldera, Bruno Cury, Carolina Meireles and Rosane Kupfer
    Citation: Diabetology & Metabolic Syndrome 2015 7:51
    Content type: Short report Published on:

  30. DPP-4 inhibitors reportedly exert effects on both alpha and beta cells, and promote the proliferation and survival of beta cells. We investigated the effects of anagliptin on structurally-impaired islets of La...

    Authors: Takanori Shinjo, Yusuke Nakatsu, Misaki Iwashita, Tomomi Sano, Hideyuki Sakoda, Hisamitsu Ishihara, Akifumi Kushiyama, Midori Fujishiro, Fusanori Nishimura and Tomoichiro Asano
    Citation: Diabetology & Metabolic Syndrome 2015 7:50
    Content type: Short report Published on:

  31. The highly active antiretroviral therapy (HAART) has altered the course of HIV infection, transforming it from a fatal illness to a chronic condition, reducing morbidity and mortality. However, this therapy ha...

    Authors: Miguel A. Guillen, Fernando A. Mejia, Jaime Villena, Christie G. Turin, Cesar P. Carcamo and Ray Ticse
    Citation: Diabetology & Metabolic Syndrome 2015 7:49
    Content type: Research Published on:

  32. Ninety percent of glucose filtered by the glomerulus is reabsorbed by a sodium-glucose cotransporter 2 (SGLT2), which is expressed mainly on the apical membrane of renal proximal tubules. Since SGLT-2-mediated...

    Authors: Nobutaka Nakamura, Takanori Matsui, Yuji Ishibashi and Sho-ichi Yamagishi
    Citation: Diabetology & Metabolic Syndrome 2015 7:48
    Content type: Research Published on:

  33. Osteoprotegerin (OPG), a soluble member of the tumor necrosis factor receptor superfamily that inhibits bone resorption, has been suggested as a potential marker of cardiovascular risk. This study aimed to ass...

    Authors: Clarisse Noël Ayina Ayina, Eugene Sobngwi, Mickael Essouma, Jean Jacques N. Noubiap, Philippe Boudou, Laurent Serge Etoundi Ngoa and Jean François Gautier
    Citation: Diabetology & Metabolic Syndrome 2015 7:47
    Content type: Short report Published on:

  34. Female abdominal obesity is associated with hyperandrogenemia (HA), but few studies have addressed the possible association between HA and metabolic syndrome (MetS) among obese women. Some studies indicate tha...

    Authors: T.G. Valderhaug, J.K. Hertel, N. Nordstrand, P.O. Dale, D. Hofsø and J. Hjelmesæth
    Citation: Diabetology & Metabolic Syndrome 2015 7:46
    Content type: Research Published on:

  35. Although the health burden of shift work has not been extensively studied, evidence suggests that it may affect the metabolic balance and cause obesity and other metabolic disorders. Sleep deprivation, circadi...

    Authors: Maria Carlota Borba Brum, Fábio Fernandes Dantas Filho, Claudia Carolina Schnorr, Gustavo Borchardt Bottega and Ticiana C. Rodrigues
    Citation: Diabetology & Metabolic Syndrome 2015 7:45
    Content type: Review Published on:

  36. Incretin therapy is feasible in patients with type 2 diabetes mellitus undergoing hemodialysis (HD). However, few studies have examined the safety and efficacy of this therapeutic approach in patients with dia...

    Authors: Yuichi Terawaki, Takashi Nomiyama, Hiroyuki Takahashi, Yoko Tsutsumi, Kunitaka Murase, Ryoko Nagaishi, Makito Tanabe, Tadachika Kudo, Kunihisa Kobayashi, Tetsuhiko Yasuno, Hitoshi Nakashima and Toshihiko Yanase
    Citation: Diabetology & Metabolic Syndrome 2015 7:44
    Content type: Research Published on:

  37. Women with gestational diabetes mellitus (GDM) are at an increased risk of developing metabolic syndrome (MetS) after delivery. Recently, the prevalence of both GDM and MetS has increased worldwide, in paralle...

    Authors: Tiina Vilmi-Kerälä, Outi Palomäki, Merja Vainio, Jukka Uotila and Ari Palomäki
    Citation: Diabetology & Metabolic Syndrome 2015 7:43
    Content type: Research Published on:

  38. Guidelines increasingly encourage the use of multivariable risk models to predict the presence of prevalent undiagnosed type 2 diabetes mellitus worldwide. However, no single model can perform well in all sett...

    Authors: Katya Masconi, Tandi E. Matsha, Rajiv T. Erasmus and Andre P. Kengne
    Citation: Diabetology & Metabolic Syndrome 2015 7:42
    Content type: Research Published on:

  39. Type 2 diabetes mellitus (T2DM) is a major and fast growing public health problem. Although obesity is considered to be the main driver of the pandemic of T2DM, a possible contribution of some environmental co...

    Authors: Elvis Ndonwi Ngwa, Andre-Pascal Kengne, Barbara Tiedeu-Atogho, Edith-Pascale Mofo-Mato and Eugene Sobngwi
    Citation: Diabetology & Metabolic Syndrome 2015 7:41
    Content type: Review Published on:

  40. Metabolic syndrome (MetS) is a clustering of cardiovascular risk factors, which is associated with diabetes mellitus and cardiovascular disease. Lifestyle interventions applied to people with MetS has consider...

    Authors: Parco M Siu, Angus P Yu, Iris F Benzie and Jean Woo
    Citation: Diabetology & Metabolic Syndrome 2015 7:40
    Content type: Research Published on:

  41. In mammals, the temperature rhythm is regulated by the circadian pacemaker located in the suprachiasmatic nuclei, and is considered a “marker rhythm”. Melatonin, the pineal gland hormone, is a major regulator ...

    Authors: Angela M Ramos-Lobo, Daniella C Buonfiglio and José Cipolla-Neto
    Citation: Diabetology & Metabolic Syndrome 2015 7:39
    Content type: Research Published on:

  42. The HSD11B1 gene is highly expressed in abdominal adipose tissue, and the enzyme it encodes catalyzes the interconversion of inactive cortisone to hormonally active cortisol. Genetic abnormalities of HSD11B1 have...

    Authors: Filipe Valvassori do Nascimento, Vanessa Piccoli, Mayara Abichequer Beer, Anize Delfino von Frankenberg, Daisy Crispim and Fernando Gerchman
    Citation: Diabetology & Metabolic Syndrome 2015 7:38
    Content type: Review Published on:

  43. There remains controversy regarding which of the anthropometric indicators best defines obesity. In this study, we compared the efficacy of using body mass index (BMI), waist circumference (WC) and waist-to-hi...

    Authors: Xiaojun Ouyang, Qinlin Lou, Liubao Gu, Gary T Ko, Yongzhen Mo, Haidi Wu and Rongwen Bian
    Citation: Diabetology & Metabolic Syndrome 2015 7:37
    Content type: Research Published on:

  45. There is a clinical imperative to improve metabolic control in the treatment of patients with type 1 diabetes, but in doing so, hypoglycemia should be avoided at all costs. Insulin analogues and the assumption...

    Authors: Beatriz D Schaan and Rafael Selbach Scheffel
    Citation: Diabetology & Metabolic Syndrome 2015 7:35
    Content type: Commentary Published on:

  46. Polymorphisms in genes encoding adiponectin (ADIPOQ) and interleukin-6 (IL6) have been associated with adiposity and obese-related phenotypes. This study investigated the relationship of ADIPOQ and IL6 gene polym...

    Authors: Raquel de Oliveira, Tamiris Invencioni Moraes, Alvaro Cerda, Mario Hiroyuki Hirata, Cristina Moreno Fajardo, Marcela Correia Sousa, Egidio Lima Dorea, Márcia Martins Silveira Bernik and Rosario Dominguez Crespo Hirata
    Citation: Diabetology & Metabolic Syndrome 2015 7:34
    Content type: Research Published on:

  47. Insulin resistance (IR) correlates closely with cardiovascular disease. C1q/TNF-related protein-3 (CTRP3) is a novel adipokine that modulates insulin activity in various diseases. This study investigated the r...

    Authors: Wuquan Deng, Changyan Li, Yuping Zhang, Jie Zhao, Mengliu Yang, Mingyuan Tian, Ling Li, Yanling Zheng, Bing Chen and Gangyi Yang
    Citation: Diabetology & Metabolic Syndrome 2015 7:33
    Content type: Research Published on:

  48. Growth-curves are an important tool for evaluating the anthropometric development in pediatrics. The different growth-curves available are based in different populations, what leads to different cut-offs.

    Authors: Henrique Nascimento, Cristina Catarino, Denisa Mendonça, Pedro Oliveira, Ana Inês Alves, Ana Filipa Medeiros, Petronila Rocha Pereira, Carla Rêgo, Helena Ferreira Mansilha, Luísa Aires, Jorge Mota, Alexandre Quintanilha, Alice Santos-Silva and Luís Belo
    Citation: Diabetology & Metabolic Syndrome 2015 7:32
    Content type: Short report Published on:

  49. Low health literacy is associated with worse glycemic control among patients with diabetes; the relationship between health literacy and blood glucose among patients without diagnosed diabetes, particularly in...

    Authors: Candace D McNaughton, Rosalynne R Korman, Edmond K Kabagambe and Seth W Wright
    Citation: Diabetology & Metabolic Syndrome 2015 7:31
    Content type: Research Published on:

  50. Pregnant women with mild gestational hyperglycemia present a high risk for hypertension and obesity, and appear to reproduce the model of metabolic syndrome in pregnancy, including hyperinsulinemia and insulin...

    Authors: Rafael B Gelaleti, Débora C Damasceno, Daisy M F Salvadori, João Paulo C Marcondes, Paula H O Lima, Glilciane Morceli, Iracema M P Calderon and Marilza V C Rudge
    Citation: Diabetology & Metabolic Syndrome 2015 7:30
    Content type: Research Published on:

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Diabetology & Metabolic Syndrome

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