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  1. The incidence of diabetes mellitus is increasing worldwide, resulting in a global epidemic. The most common type, the type 2 diabetes mellitus, constitutes of 90–95 % of the cases and is characterized by the acti...

    Authors: Carlos Gabriel de Lade, João Carlos Bouzas Marins, Luciana Moreira Lima, Cristiane Junqueira de Carvalho, Robson Bonoto Teixeira, Maicon Rodrigues Albuquerque, Janice Sepúlveda Reis and Paulo Roberto dos Santos Amorim
    Citation: Diabetology & Metabolic Syndrome 2016 8:13
    Content type: Research Published on:

  2. Whereas an increase of neck circumference (NC) had been recently identified as a new independent cardiovascular disease (CVD) and metabolic syndrome risk factor, similar assessments concerning screen-detected ...

    Authors: Mykolay Khalangot, Vitaliy Gurianov, Nadia Okhrimenko, Igor Luzanchuk and Victor Kravchenko
    Citation: Diabetology & Metabolic Syndrome 2016 8:12
    Content type: Research Published on:

  3. Inflammation is an early event in the development of diabetes type 2 (T2D). Cichorium intybus L. (chicory) possesses anti-inflammatory action. We compared the anti-inflammatory aspect of aqueous chicory seed extr...

    Authors: Lotfollah Rezagholizadeh, Yasin Pourfarjam, Azin Nowrouzi, Manuchehr Nakhjavani, Alipasha Meysamie, Nasrin Ziamajidi and Peyman S. Nowrouzi
    Citation: Diabetology & Metabolic Syndrome 2016 8:11
    Content type: Research Published on:

  4. The deep subcutaneous adipose tissue (dSAT) is closely related to the obesity-associated complications similarly to the characteristics of visceral adipose tissue (VAT). However, the association between dSAT a...

    Authors: Se-Hong Kim, Ju-hye Chung, Sang-Wook Song, Won Sang Jung, Yun-Ah Lee and Ha-Na Kim
    Citation: Diabetology & Metabolic Syndrome 2016 8:10
    Content type: Research Published on:

  5. In most individuals, obesity and insulin resistance coexist. However, some individuals have excessive adipose tissue mass but remain insulin sensitive. Moreover, lean individuals can develop acute inflammation...

    Authors: Samuel D. Moscavitch, Hye C. Kang, Rubens A. C. Filho, Evandro T. Mesquita, Hugo C. C. F. Neto and Maria L. G. Rosa
    Citation: Diabetology & Metabolic Syndrome 2016 8:9
    Content type: Research Published on:

  6. The consumption of hyperlipidic and hypercaloric diet is considered a major factor to promote obesity and the consumption of food with antioxidant properties, like Juçara (Euterpe edulis Mart), could be a tool to...

    Authors: L. M. Oyama, F. P. Silva, J. Carnier, D. A. de Miranda, A. B. Santamarina, E. B. Ribeiro, C. M. Oller do Nascimento and V. V. de Rosso
    Citation: Diabetology & Metabolic Syndrome 2016 8:8
    Content type: Research Published on:

  7. The chronic care model (CCM) uses a systematic approach to restructure health care systems. The aim of this systematic review was to examine studies that evaluated different elements of the CCM in patients wi...

    Authors: Deise Regina Baptista, Astrid Wiens, Roberto Pontarolo, Lara Regis, Walleri Christine Torelli Reis and Cassiano Januário Correr
    Citation: Diabetology & Metabolic Syndrome 2016 8:7
    Content type: Review Published on:

  8. Recently, we reported signs of inflammation (raised IL-8, reduced miR-146a) and signs of vascular repair (raised HGF) in the serum of Ecuadorian patients with type 2 diabetes (T2D). In contrast, we found that ...

    Authors: Lucy Baldeón Rojas, Karin Weigelt, Harm de Wit, Behiye Ozcan, Adri van Oudenaren, Fernando Sempértegui, Eric Sijbrands, Laura Grosse, Anton-Jan van Zonneveld, Hemmo A. Drexhage and Pieter J. M. Leenen
    Citation: Diabetology & Metabolic Syndrome 2016 8:6
    Content type: Research Published on:

  9. The vascular effects exerted by GLP-1 are mediated by several synergistic mechanisms such as involvement of nitric oxide and natriuresis. Recently, it was demonstrated that atrial natriuretic peptide (ANP) is ...

    Authors: David Nathanson, Mats Frick, Bengt Ullman and Thomas Nyström
    Citation: Diabetology & Metabolic Syndrome 2016 8:5
    Content type: Research Published on:

  10. Deregulation of glycemic and glycated hemoglobin (HbA1) levels accelerate the progression of cardiovascular complications in type 1 diabetes mellitus (T1DM). The aim of this study was to investigate the associati...

    Authors: Sandra de Oliveira, Dahan da Cunha Nascimento, Ramires Alsamir Tibana, Samuel Lima de Oliveira, Ivo Vieira de Sousa Neto, Roberta Kelly Menezes Maciel Falleiros, Leonardo Garcia Miranda, Hermelinda Cordeiro Pedrosa, James Wilfred Navalta, Guilherme Borges Pereira and Jonato Prestes
    Citation: Diabetology & Metabolic Syndrome 2016 8:4
    Content type: Research Published on:

  11. We carried out a case–control study in patients with type 2 diabetes mellitus (T2DM) to evaluate the association between seven single nucleotide polymorphisms (SNPs) previously described to be linked to diabet...

    Authors: Marjoriê P. Buffon, Mariana P. Carpena, Denise A. Sortica, Andressa Santer, Rodrigo Carlessi, Bianca M. de Souza, Maria I. Edelweiss, Milton Berger, Daisy Crispim and Luís H. Canani
    Citation: Diabetology & Metabolic Syndrome 2016 8:3
    Content type: Research Published on:

  12. Diabetes mellitus (DM) is a public health issue, affecting around 382 million people worldwide. In order to achieve glycemic goals, insulin therapy is the frontline therapy for type 1 DM patients; for patients...

    Authors: Freddy Goldberg Eliaschewitz and Tânia Barreto
    Citation: Diabetology & Metabolic Syndrome 2016 8:2
    Content type: Review Published on:

  13. To compare the effects of nateglinide and rosiglitazone on inflammatory markers, GLP-1 levels and metabolic profile in patients with type 2 diabetes (DM2).

    Authors: Glauce Cordeiro Ulhôa Tostes, Maria Rosário Cunha, Rosa Tsumeshiro Fukui, Márcia Regina Silva Correia, Dalva Marreiro Rocha, Rosa Ferreira dos Santos and Maria Elizabeth Rossi da Silva
    Citation: Diabetology & Metabolic Syndrome 2016 8:1
    Content type: Research Published on:

  14. Myeloperoxidase (MPO) is a lysosomal hemoprotein found in the azurophilic granules in neutrophils. Myeloperoxidase plays an important role in oxygen-dependent killing of bacteria, fungi, virus and malignant ce...

    Authors: Mustafa Unubol, Irfan Yavasoglu, Firuzan Kacar, Engin Guney, Imran Kurt Omurlu, Mevlut Ture, Gurhan Kadikoylu and Zahit Bolaman
    Citation: Diabetology & Metabolic Syndrome 2015 7:119
    Content type: Research Published on:

  15. Diabetic kidney disease (DKD) is a chronic complication of diabetes mellitus, which is considered a worldwide epidemic. Several studies have been developed in order to elucidate possible genetic factors involv...

    Authors: Marjoriê Piuco Buffon, Denise Alves Sortica, Fernando Gerchman, Daisy Crispim and Luís Henrique Canani
    Citation: Diabetology & Metabolic Syndrome 2015 7:118
    Content type: Review Published on:

  16. Progranulin (PGRN) is a cysteine rich secreted protein, expressed in epithelial cells, immune cells, neurons, and adipocytes. It was first identified for its growth factor-like properties, being involved in ea...

    Authors: Bruna Bellincanta Nicoletto and Luis Henrique Canani
    Citation: Diabetology & Metabolic Syndrome 2015 7:117
    Content type: Research Published on:

  17. Diabetic retinopathy is the main cause of preventable blindness in the economically active population in western countries. Diabetic retinopathy screening is effective in preventing blindness and can be perfor...

    Authors: Fernando Korn Malerbi, Paulo Henrique Morales, Michel Eid Farah, Karla Rezende Guerra Drummond, Tessa Cerqueira Lemos Mattos, André Araújo Pinheiro, Felipe Mallmann, Ricardo Vessoni Perez, Franz Schubert Lopes Leal, Marília Brito Gomes and Sergio Atala Dib
    Citation: Diabetology & Metabolic Syndrome 2015 7:116
    Content type: Research Published on:

  18. Hyperglycemia has been associated with decreased blood flow in various organs, leading to tissue damage and dysfunctions. Exercise training (ET) is known to promote beneficial changes in the autonomic nervous ...

    Authors: Sarah Cristina Ferreira Freitas, Ângela d’Avila Harthmann, Bruno Rodrigues, Maria-Cláudia Irigoyen and Kátia De Angelis
    Citation: Diabetology & Metabolic Syndrome 2015 7:115
    Content type: Research Published on:

  19. Inpatient hyperglycemia is associated with adverse outcomes in hospitalized patients, with or without known diabetes. The adherence to American College of Endocrinology and American Diabetes Association guidel...

    Authors: Marcos Tadashi Kakitani Toyoshima, Alexandre Barbosa Câmara de Souza, Sharon Nina Admoni, Priscilla Cukier, Simão Augusto Lottenberg, Ana Claudia Latronico and Márcia Nery
    Citation: Diabetology & Metabolic Syndrome 2015 7:114
    Content type: Short report Published on:

  20. Diabetes and its complications are substantial causes of morbidity and mortality, and caused approximately 5.1 million deaths worldwide in 2013. Early detection and treatment of diabetes complications can prev...

    Authors: Deise Regina Baptista, Rubia Daniela Thieme, Walleri Christini Torelli Reis, Roberto Pontarolo and Cassyano Januário Correr
    Citation: Diabetology & Metabolic Syndrome 2015 7:113
    Content type: Research Published on:

  22. Metabolic syndrome (MetS) contains a cluster of cardiovascular risk factors. People with MetS are more susceptible to cardiovascular disease, diabetes mellitus, and cancer. Endothelin-1 (ET-1) and matrix metal...

    Authors: A. P. Yu, B. T. Tam, W. Y. Yau, K. S. Chan, S. S. Yu, T. L. Chung and P. M. Siu
    Citation: Diabetology & Metabolic Syndrome 2015 7:111
    Content type: Research Published on:

  23. Elevated levels of fibrinogen may contribute to a prothrombotic state. Cross-sectional studies suggest fibrinogen possibly linked with MetS/its components, while results of cohort studies remain controversial....

    Authors: Lijie Ding, Chengqi Zhang, Guang Zhang, Tao Zhang, Min Zhao, Xiaokang Ji, Zhongshang Yuan, Ruihong Liu, Fang Tang and Fuzhong Xue
    Citation: Diabetology & Metabolic Syndrome 2015 7:110
    Content type: Research Published on:

  24. Over recent decades, Brazilian mortality registration has undergone increasing improvement in terms of completeness and quality in cause of death reporting. These improvements, however, complicate the descript...

    Authors: Maria Inês Schmidt, Bruce B. Duncan, Lenice Ishitani, Glaura da Conceição Franco, Daisy Maria Xavier de Abreu, Gustavo C. Lana and Elisabeth França
    Citation: Diabetology & Metabolic Syndrome 2015 7:109
    Content type: Research Published on:

  25. It is well-established that nonalcoholic fatty liver disease (NAFLD) is associated with type 2 diabetes mellitus (T2DM). Complement-C1q TNF-related protein 5 (CTRP5) is a novel adipokine involved in the regula...

    Authors: Solaleh Emamgholipour, Nariman Moradi, Maani Beigy, Parisa Shabani, Reza Fadaei, Hossein Poustchi and Mahmood Doosti
    Citation: Diabetology & Metabolic Syndrome 2015 7:108
    Content type: Research Published on:

  26. Hyperglycemia and insulin resistance often develop cardiovascular and nephrological dysfunction in diabetic patients. Sitagliptin is used to treat diabetes and showed potential benefit in lowering increased bl...

    Authors: Md. Ashraful Alam, Mohammed Riaz Hasan Chowdhury, Preeti Jain, Md. Abu Taher Sagor and Hasan Mahmud Reza
    Citation: Diabetology & Metabolic Syndrome 2015 7:107
    Content type: Research Published on:

  27. Using patient data from the GetGoal-Duo1, -L, and L-Asia trials, the objectives of this study were to evaluate and compare the impact of lixisenatide once-daily add-on treatment to basal insulin therapy ±oral ...

    Authors: Kazuhiro Eto, Yusuke Naito and Yutaka Seino
    Citation: Diabetology & Metabolic Syndrome 2015 7:106
    Content type: Research Published on:

  28. The raising prevalence of weight excess and of non-communicable diseases in indigenous populations, as well as changes in food consumption and reduction in the frequency and intensity of physical activity, sug...

    Authors: Luana Padua Soares, Amaury Lelis Dal Fabbro, Anderson Soares Silva, Daniela Saes Sartorelli, Luciana Ferreira Franco, Patrícia Chamadoira Kuhn, Regina Santiago Moises, João Paulo Botelho Vieira-Filho and Laércio Joel Franco
    Citation: Diabetology & Metabolic Syndrome 2015 7:105
    Content type: Research Published on:

  29. Insulin resistance with elevated glucose is a risk factor for non-alcoholic steatohepatitis (NASH). We investigated the effects of the sodium glucose cotransporter 2 (SGLT2) inhibitor luseogliflozin on NASH de...

    Authors: Shirong Qiang, Yusuke Nakatsu, Yasuyuki Seno, Midori Fujishiro, Hideyuki Sakoda, Akifumi Kushiyama, Keiichi Mori, Yasuka Matsunaga, Takeshi Yamamotoya, Hideaki Kamata and Tomoichiro Asano
    Citation: Diabetology & Metabolic Syndrome 2015 7:104
    Content type: Short report Published on:

  30. Diabetic kidney disease (DKD) is the leading cause of end stage renal disease worldwide and is associated with increased cardiovascular mortality. The endothelin system has been implicated in the pathogenesis ...

    Authors: Claudete M. Zanatta, Daisy Crispim, Denise A. Sortica, Lucas P. Klassmann, Jorge L. Gross, Fernando Gerchman and Luís H. Canani
    Citation: Diabetology & Metabolic Syndrome 2015 7:103
    Content type: Research Published on:

  31. Metabolic syndrome (MetS) becomes a serious society health problem. The main risk factors of MetS are related to the increased risk of cardiovascular diseases, appearance of stroke, type 2 diabetes mellitus an...

    Authors: Laura KazlauskienÄ—, JÅ«ratÄ— ButnorienÄ— and Antanas Norkus
    Citation: Diabetology & Metabolic Syndrome 2015 7:102
    Content type: Research Published on:

  32. Permanent neonatal diabetes mellitus (PNDM) is a rare disorder, characterized by uncontrolled hyperglycemia diagnosed during the first 6 months of life. In general, PNDM has a genetic origin and most frequentl...

    Authors: Adriana Mangue Esquiaveto-Aun, Maricilda Palandi De Mello, Maria Fernanda Vanti Macedo Paulino, Walter José Minicucci, Gil Guerra-Júnior and Sofia Helena Valente De Lemos-Marini
    Citation: Diabetology & Metabolic Syndrome 2015 7:101
    Content type: Short report Published on:

  33. Insulin resistance is a major component of metabolic syndrome, type 2 Diabetes Mellitus (T2DM) and coronary artery disease (CAD). Although important in T2DM, its role as a predictor of CAD in non-diabetic pati...

    Authors: Márcio Mossmann, Marco V. Wainstein, Sandro C. Gonçalves, Rodrigo V. Wainstein, Gabriela L. Gravina, Marlei Sangalli, Francine Veadrigo, Roselene Matte, Rejane Reich, Fernanda G. Costa and Marcello C. Bertoluci
    Citation: Diabetology & Metabolic Syndrome 2015 7:100
    Content type: Research Published on:

  34. Hyperprolactinemia has been associated with changes in body composition and metabolic abnormalities. Normalization of prolactin (PRL) with dopamine agonists has been found to reverse these abnormalities. This ...

    Authors: Nazir A. Pala, Bashir A. Laway, Raiz A. Misgar and Rayees A. Dar
    Citation: Diabetology & Metabolic Syndrome 2015 7:99
    Content type: Research Published on:

  35. Diabetes mellitus is one of the most important risk factors for atherosclerosis. However, the mechanisms underlying high-glucose-induced atherosclerosis remain unclear. This study was designed to observe the e...

    Authors: Xiao-Yan Zhao, Xiao-Fang Wang, Ling Li, Li Zhang, De-Liang Shen, Dan-Hua Li, Qiang-Song Jin and Jin-Ying Zhang
    Citation: Diabetology & Metabolic Syndrome 2015 7:98
    Content type: Research Published on:

  37. The escalating rate of diabetes’ has prompted researchers around the world to explore for early markers. A deficit of functional β-cell mass plays a central role in the pathophysiology of type 2 diabetes. The REG

    Authors: Sadaf Saleem Uppal, Abdul Khaliq Naveed, Saeeda Baig and Bushra Chaudhry
    Citation: Diabetology & Metabolic Syndrome 2015 7:96
    Content type: Research Published on:

    The Erratum to this article has been published in Diabetology & Metabolic Syndrome 2016 8:20

  39. Authors: Guilherme Coutinho Kullmann Duarte, Tais Silveira Assmann, Égina Marina Barbosa Martins, Mariana Lopes dos Santos, Luis Henrique Canani and Daisy Crispim
    Citation: Diabetology & Metabolic Syndrome 2015 7(Suppl 1):A215
    Content type: Meeting abstract Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  44. Authors: Fabio Vasconcellos Comim, Etiane Tatsch, Bruna Hausen, Juliana Wispel, Leo Canterle Dal Osto, Rizzi Adhan de Viera, Paola Roehrs Colpo, Pietra Zorzo, Lucas Venturini Zottele, Karen Koff da Costa, Rafael Noal Moresco and Melissa Orlandin Premaor
    Citation: Diabetology & Metabolic Syndrome 2015 7(Suppl 1):A144
    Content type: Meeting abstract Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  45. Authors: Livia Silveira Mastella, Leticia Schwerz Weinert, Vanessa Gnielka, Vânia Naomi Hirakata, Maria Lúcia Rocha Oppermann, Sandra Pinho Silveiro and Angela de Azevedo Jacob Reichelt
    Citation: Diabetology & Metabolic Syndrome 2015 7(Suppl 1):A81
    Content type: Meeting abstract Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  46. Authors: Thaís Leal Silva, Luana Alves Freitas Afiune, Rafaianne Queiroz de Moraes Souza, Thaigra de Sousa Soares, Thalita Bohnen Carneiro, Madilene Francely Américo, Kleber Eduardo de Campos and Gustavo Tadeu Volpato
    Citation: Diabetology & Metabolic Syndrome 2015 7(Suppl 1):A77
    Content type: Meeting abstract Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  47. Authors: Ana Paula Bouças Kochenborger, Ana Paula Kutscher Ripoll, Bianca Marmontel de Souza, Pamela Sachs Nique, Denise Alves Sortica, Natali Cardoso, Sandra Pinho Silveiro, Leticia Schwerz Weinert, Sergio Hofmeister de Almeida Martins Costa, Luís Henrique Canani and Daisy Crispim
    Citation: Diabetology & Metabolic Syndrome 2015 7(Suppl 1):A75
    Content type: Meeting abstract Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  48. Authors: Marcos Oliveira Pires de Almeida, Leyna Leite Santos, Denise Dantas Lima, Taciana Borges Cavalcanti, Amanda Aleixo, Vanessa Silva de Almeida, Diego de Sousa Dantas, Bárbara Bernardo Silva, Evandro Cabral de Brito and Paulo André Freire Magalhães
    Citation: Diabetology & Metabolic Syndrome 2015 7(Suppl 1):A42
    Content type: Meeting abstract Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  49. Authors: Bárbara Limberger Nedel, Leticia Maria Tedesco Silva, Monique de Moura Machado, Rodrigo Soares de Souza Marques, Leonardo de Andrade Mesquita, Luciana Pavan Antoniolli, Tassia Cividanes Pazinato, Vanessa Piccoli, Mayara Abichequer Beer, Anize Delfino von Frankenberg and Fernando Gerchman
    Citation: Diabetology & Metabolic Syndrome 2015 7(Suppl 1):A38
    Content type: Meeting abstract Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  50. Authors: Cybelle da Silva Nery, Marcos Paulo Galdino Coutinho, Deniele Bezerra Lós, Kamilla Dinah Santos de Lira, Filipe Barbosa Cunha de Miranda, Ana Carolina Salvador de Lucena, Ana Camila Nobre de Lacerda Brito, Silvia Luana Ramos Marques, Márcio Almeida Bezerra and Sílvia Regina Arruda de Moraes
    Citation: Diabetology & Metabolic Syndrome 2015 7(Suppl 1):A9
    Content type: Meeting abstract Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

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