Table 1 Heterogeneity and pleiotropy test results of genetic variants
From: Causal effect of gut microbiota and diabetic nephropathy: a Mendelian randomization study
Gut microbiota | Heterogeneity | Pleiotropy | MR-PRESSO | |||||
|---|---|---|---|---|---|---|---|---|
MR Egger | IVW | MR Egger regression | Global Test | |||||
Cochran’s Q | P-value | Cochran’s Q | P-value | Egger intercept | P-value | RSSobs | P-value | |
Order Bacteroidales | 15.356 | 0.167 | 15.497 | 0.215 | 0.009 | 0.756 | 17.487 | 0.271 |
Genus Eubacterium ventriosum | 4.886 | 0.978 | 4.928 | 0.987 | -0.008 | 0.840 | 5.532 | 0.992 |
Genus Ruminococcus gauvreauii | 7.149 | 0.521 | 8.626 | 0.473 | 0.049 | 0.259 | 10.636 | 0.517 |
Genus Akkermansia | 9.237 | 0.323 | 9.267 | 0.413 | 0.006 | 0.876 | 11.398 | 0.471 |
Genus Coprococcus 1 | 4.362 | 0.930 | 5.285 | 0.917 | -0.024 | 0.359 | 6.226 | 0.935 |
Genus Erysipelotrichaceae (UCG003) | 8.428 | 0.866 | 8.476 | 0.903 | 0.006 | 0.829 | 9.624 | 0.933 |
Genus Marvinbryantia | 4.919 | 0.766 | 5.135 | 0.822 | -0.022 | 0.655 | 6.219 | 0.846 |
Genus Parasutterella | 4.045 | 0.969 | 6.514 | 0.888 | 0.061 | 0.144 | 7.858 | 0.893 |