Fig. 4

Meta-analysis and forest plot of effects of CB1 antagonist and knockout on second outcomes including blood glucose (A), body weight (B), metabolic and inflammatory related index (MCP-1, IL1β, IL18, TNF-α and TGF-β mRNA level, respectively) (C–G). N1 denotes the number of animals in the treatment group and N2 denotes the number of animals in the control group. The size of the square indicates the weight (%) of each study, the horizontal line shows the 95% confidence interval (95%-CI) of the individual standardized mean difference (SMD), and the black diamond represents the combined SMD and 95%-CI