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Fig. 4 | Diabetology & Metabolic Syndrome

Fig. 4

From: High glucose-induced injury in human umbilical vein endothelial cells is alleviated by vitamin D supplementation through downregulation of TIPE1

Fig. 4

?Overexpression of TIPE1 reverses the effects of Vitamin D in ROS and autophagy in human umbilical vein endothelial cells treated by high glucose. (A) ROS level was detected by DCFH-DA. (B) Autophagy flux was tested by mCherry-GFP-LC3B assay. (C) Transmission microscope was performed to check the autophagosome. Ctrl, a normal concentration of glucose (5.6 mM); G, high glucose treatment; G+VD, high glucose plus vitamin D treatment; G+VD+pc-NC, high glucose plus vitamin D treatment as well as pc-NC transfection; G+VD+pc-TIPE1, high glucose plus vitamin D treatment as well as pc-TIPE1 transfection. *P<0.05, **P<0.01

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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