Metabolite | Pathway | log2 (FC) | P value | VIP | ORa | 95%CI | AUC | |||
---|---|---|---|---|---|---|---|---|---|---|
T1D vs. CON (serum) | ||||||||||
 5-Hydroxy-L-tryptophan | Tryptophan metabolism | 0.4154 | 0.026 | 0.8087 | 1.777 | 1.059–2.981 | 0.6236 | |||
 5-Methoxyindoleacetate | Tryptophan metabolism | 0.7270 |  < 0.001 | 1.0660 | 6.279 | 2.754–14.315 | 0.7358 | |||
 4-(2-Aminophenyl)-2,4-dioxobutanoate | Tryptophan metabolism | 0.4918 | 0.001 | 0.9853 | 3.515 | 1.689–7.312 | 0.7196 | |||
 4-Pyridoxic acid | Vitamin B6 metabolism | 1.3753 | 0.006 | 0.7594 | 3.939 | 1.596–9.721 | 0.7263 | |||
 Chitobiose | Amino sugar and nucleotide sugar metabolism | 0.8174 |  < 0.001 | 0.9247 | 2.755 | 1.535–4.943 | 0.7336 | |||
 Glycochenodeoxycholic acid 3-glucuronide | Pentose and glucuronate interconversions | 1.1391 | 0.001 | 0.7707 | 2.342 | 1.528–3.590 | 0.7565 | |||
 Deoxycholic acid glycine conjugate | Bile acid biosynthesis | 1.4009 |  < 0.001 | 0.9400 | 2.080 | 1.318–3.824 | 0.7536 | |||
 Sphinganine | Sphingolipid metabolism | − 0.6070 | 0.001 | 0.8390 | 0.348 | 0.163–0.742 | 0.6588 | |||
 L-beta-aspartyl-L-serine | – | 0.6399 | 0.003 | 0.7076 | 1.786 | 1.065–2.993 | 0.7064 | |||
T1D vs. CON (urine) | ||||||||||
 Thromboxane B3 | – | 0.4821 | 0.036 | 0.8661 | 1.827 | 1.022- 3.266 | 0.6669 | |||
 Hypoxanthine | Purine metabolism | − 0.3541 | 0.009 | 1.1453 | – | – | 0.6415 | |||
 N6,N6,N6-Trimethyl-L-lysine | Lysine degradation | 0.7730 | 0.048 | 0.4991 | – | – | 0.5994 | |||
 Withanolide B | Ubiquinone and other terpenoid-quinone biosynthesis | 0.6992 | 0.041 | 0.6403 | 1.802 | 1.233- 2.633 | 0.6464 | |||
 6-Hydroxy-5-methoxyindole glucuronide | Pentose and glucuronate interconversions | − 0.6375 |  < 0.001 | 1.5086 | 0.271 | 0.135–0.545 | 0.6961 | |||
TIR-L vs. TIR-H (serum) | ||||||||||
 5-Hydroxy-L-tryptophan | Tryptophan metabolism | − 0.6442 | 0.040 | 1.6627 | – | – | 0.7250 | |||
 4-Pyridoxic acid | Vitamin B6 metabolism | − 0.9901 | 0.109 | 1.8041 | – | – | 0.6542 | |||
 Deoxycholic acid glycine conjugate | Bile acid biosynthesis | 1.1396 | 0.113 | 1.2084 | – | – | 0.6375 | |||
 Chitobiose | Amino sugar and nucleotide sugar metabolism | − 0.1320 | 0.736 | 1.2366 | – | – | 0.5125 | |||
 Mevalonolactone | – | − 1.8308 |  < 0.001 | 2.6453 | 0.054 | 0.008–0.368 | 0.9375 | |||
 L-beta-aspartyl-L-serine | – | − 0.4808 | 0.113 | 1.3370 | – | – | 0.7292 | |||
TIR-L vs. TIR-H (urine) | ||||||||||
 Thromboxane B3 | – | − 0.7022 | 0.024 | 1.5800 | 0.201 | 0.039–1.023 | 0.7218 | |||
 N6,N6,N6-Trimethyl-L-lysine | Lysine degradation | − 1.2279 | 0.055 | 1.1390 | 0.304 | 0.101–0.908 | 0.7068 | |||
 Hypoxanthine | Purine metabolism | − 0.4618 | 0.064 | 1.0109 | 0.075 | 0.008–0.739 | 0.7030 | |||
 Phenylbutyrylglutamine | – | − 2.2585 | 0.027 | 1.3021 | 0.144 | 0.033–0.633 | 0.7782 |