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Table 2 Odd ratios for hypertension by different liver function indicators

From: Liver indicators affecting the relationship between BMI and hypertension in type 2 diabetes: a mediation analysis

 

Overall

Female

Male

(n = 1715)

(n = 871)

(n = 844)

ALT

 Q1 (≤ 15 U/L)

1.00 (ref.)

1.00 (ref.)

1.00 (ref.)

 Q2 (15–21 U/L)

1.267 (0.956–1.677)

1.117 (0.766–1.627)

1.462 (0.944–2.263)

 Q3 (21–30 U/L)

1.505 (1.114–2.032)

1.239 (0.817–1.879)

1.839 (1.171–2.888)

 Q4 (≥ 30 U/L)

1.790 (1.341–2.388)

1.659 (1.097–2.508)

1.877 (1.224–2.877)

 P for trend

0.001

0.110

0.020

 Per SD increase

1.222 (1.098–1.359)

1.240 (1.067–1.441)

1.168 (1.004–1.358)

AST

 Q1 (≤ 16 U/L)

1.00 (ref.)

1.00 (ref.)

1.00 (ref.)

 Q2 (16–20 U/L)

1.178 (0.886–1.565)

1.146 (0.776–1.694)

1.202 (0.786–1.839)

 Q3 (20–26 U/L)

1.233 (0.908–1.676)

1.210 (0.784–1.868)

1.225 (0.786–1.911)

 Q4 (≥ 26 U/L)

1.667 (1.256–2.213)

1.464 (0.983–2.180)

1.800 (1.189–2.723)

 P for trend

0.004

0.309

0.032

 Per SD increase

1.207 (1.085–1.342)

1.203 (1.037–1.395)

1.185 (1.012–1.387)

AST/ALT

 Q1 (≤ 0.78)

1.00 (ref.)

1.00 (ref.)

1.00 (ref.)

 Q2 (0.78–0.95)

1.128 (0.843–1.511)

0.972 (0.614–1.539)

1.290 (0.881–1.890)

 Q3 (0.95–1.21)

0.930 (0.688–1.258)

0.811 (0.517–1.274)

1.145 (0.753–1.742)

 Q4 (≥ 1.21)

0.647 (0.476–0.878)

0.679 (0.433–1.064)

0.608 (0.392–0.944)

 P for trend

0.002

0.251

0.007

 Per SD increase

0.851 (0.763–0.949)

0.850 (0.730–0.990)

0.871 (0.748–1.015)

GGT

 Q1 (≤ 18 U/L)

1.00 (ref.)

1.00 (ref.)

1.00 (ref.)

 Q2 (18–27 U/L)

1.541 (1.154–2.057)

1.546 (1.067–2.239)

1.497 (0.921–2.433)

 Q3 (27–46 U/L)

1.715 (1.262–2.330)

1.591 (1.040–2.434)

1.723 (1.062–2.796)

 Q4 (≥ 46 U/L)

3.064 (2.239–4.194)

2.330 (1.489–3.648)

3.452 (2.129–5.596)

 P for trend

< 0.001

0.002

< 0.001

 Per SD increase

1.234 (1.093–1.393)

1.150 (0.989–1.336)

1.248 (1.048–1.486)

  1. Models were adjusted for age, sex, diabetes duration, current smoking, FPG, HbA1c, anti-diabetic therapy, family history of diseases, including diabetes, hypertension, obesity, hyperlipidemia
  2. Data in the parentheses are 95% uncertainty intervals; OR indicates odds ratio
  3. Q1–Q4 indicate 25th–75th percentile