Connections between body composition and dysregulation of islet α- and β-cells in type 2 diabetes

Table 2 Pearson’s correlation of body composition with islet α- and β-cell functions in all patients with T2D

Variables		lnISI_C-peptide	lnAUC_C-peptide	Fasting Glucagon	AUC_glucagon
Bone-free mass	r	− 0.266	0.211	− 0.123	− 0.146
Bone-free mass	p	< 0.001	< 0.001	0.001	< 0.001
Total fat mass	r	− 0.297	0.303	0.020	0.003
Total fat mass	p	< 0.001	< 0.001	0.588	0.941
Total lean mass	r	− 0.157	0.079	− 0.181	− 0.200
Total lean mass	p	< 0.001	< 0.001	< 0.001	< 0.001
Total fat/lean ratio	r	− 0.183	0.248	0.132	0.136
Total fat/lean ratio	p	< 0.001	< 0.001	< 0.001	< 0.001
Trunk fat mass	r	− 0.330	0.317	0.006	0.005
Trunk fat mass	p	< 0.001	< 0.001	0.882	0.885
Trunk lean mass	r	− 0.177	0.086	− 0.158	− 0.176
Trunk lean mass	p	< 0.001	0.021	< 0.001	< 0.001
Trunk fat/lean ratio	r	− 0.231	0.282	0.104	0.113
Trunk fat/lean ratio	p	< 0.001	< 0.001	0.005	0.002
Limb fat mass	r	− 0.220	0.254	0.043	0.021
Limb fat mass	p	< 0.001	< 0.001	0.243	0.571
Limb lean mass	r	− 0.139	0.078	− 0.196	− 0.214
Limb lean mass	p	< 0.001	< 0.001	< 0.001	< 0.001
Limb fat/lean ratio	r	− 0.105	0.181	0.149	0.148
Limb fat/lean ratio	p	0.005	< 0.001	< 0.001	< 0.001
ASMI	r	− 0.159	0.113	− 0.178	− 0.185
ASMI	p	< 0.001	< 0.001	< 0.001	< 0.001

Bone-free mass sum total fat and muscle mass, ASMI appendicular skeletal muscle index, ISI_C-peptide C-peptide-substituted Matsuda index, lnISI_C-peptide natural log-transformed ISI_C-peptide, AUC_C-peptide C-peptide area under curve during OGTT, lnAUC_C-peptide natural log-transformed AUC_C-peptide

ISSN: 1758-5996