Skip to main content
Fig. 6 | Diabetology & Metabolic Syndrome

Fig. 6

From: Didymin protects pancreatic beta cells by enhancing mitochondrial function in high-fat diet-induced impaired glucose tolerance

Fig. 6

Didymin attenuates inflammation, improves GSIS and inhibits apoptosis through enhancing mitochondrial function. (A) Glucose-stimulated insulin secretion (GSIS) and Glucose-stimulated index (GSI) calculation. (B) Western blot measurement of intracellular insulin content. (C) Western blot measurement of TNF-α, IL-6 and IL-1β in INS-1 cells. (D) Relative mRNA expression of TNF-α, IL-6 and IL-1β. (E) Western blot analysis of the cleaved-PARP, PARP, Bax, Bcl2, cleaved-caspase3, and caspase3 proteins in INS-1 cells. Data are expressed as mean ± SD (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 PA + Didymin vs. PA + Didymin + Rotenone. # P < 0.05, ## P < 0.01, ### P < 0.001, #### P < 0.0001 PA vs. PA + Didymin.

Back to article page

Diabetology & Metabolic Syndrome

ISSN: 1758-5996

Contact us