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Fig. 1 | Diabetology & Metabolic Syndrome

Fig. 1

From: Didymin protects pancreatic beta cells by enhancing mitochondrial function in high-fat diet-induced impaired glucose tolerance

Fig. 1

Didymin improves PBC insulin secretion function. (A) Graphical description of experimental design of this study. (B) Intraperitoneal glucose tolerance tests (IPGTT) (n = 5). (C) Area underneath IPGTT curve (AUC) (n = 5). (D) Plasma insulin responses (t = 0- and 30-min post) during IPGTT (n = 5). (E) Analysis of insulin granules in PBCs by electron microscopy, the red arrow indicates insulin granules, the green arrow indicates mitochondria, and the green circle points out damaged mitochondrial membrane. (F) Cell viability of INS-1 cells treated with PA and different concentrations of Didymin (n = 5). (G) Glucose-stimulated insulin secretion (GSIS) of INS-1 cells (n = 4). (H) Glucose-stimulated index (GSI) calculation. Intracellular insulin content of INS-1 cells after high glucose stimulation measured by (I) Western blot (n = 4) and (G) ELISA (n = 4). (K) Relative mRNA expression of insulin in INS-1 cells (n = 4). Data are expressed as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 DIO/PA vs. DIO + Didymin/PA + Didymin. # P < 0.05, ## P < 0.01, ### P < 0.001, #### P < 0.0001 control vs. DIO/PA.

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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