From: Association between serum PCSK9 and coronary heart disease in patients with type 2 diabetes mellitus
Variables | PCSK9 concentration (ng/mL) | p value | |||
---|---|---|---|---|---|
 | Q1: < 432.98 | Q2: 432.98–521.98 | Q3: 521.98–621.24 | Q4: > 621.24 |  |
Clinical characteristics | Â | Â | Â | Â | Â |
N (%) | 748 (25.07%) | 744 (24.93%) | 746 (25.00%) | 746 (25.00%) | – |
Age (years) | 57.07 ± 9.19 | 57.59 ± 9.94 | 56.94 ± 10.03 | 58.31 ± 10.33 | 0.440 |
Male (%) | 437 (58.42%) | 419 (56.32%) | 451 (60.46%) | 425 (56.97%) | 0.378 |
BMI (kg/m2) | 24.91 ± 2.82 | 25.55 ± 3.54 | 25.47 ± 2.98 | 24.97 ± 2.85 | 0.203 |
Hypertension (%) | 501 (66.98%) | 532 (71.51%) | 541 (72.52%) | 510 (68.36%) | 0.066 |
Smoking (%) | 220(29.41%) | 193(25.94%) | 215(28.82%) | 210(28.15%) | 0.467 |
Alcohol consumption (%) | 232(31.02%) | 236(31.72%) | 216(28.95%) | 203(27.21%) | 0.214 |
Family history of CHD (%) | 194(25.94%) | 201(27.02%) | 220(29.49%) | 236(31.64%) | 0.067 |
Family history of MD (%) | 272(36.36%) | 293(39.38%) | 280(37.53%) | 290(38.87%) | 0.623 |
Laboratory variables | Â | Â | Â | Â | Â |
FPG (mmol/L) | 7.62 ± 1.10 | 7.59 ± 1.11 | 7.80 ± 1.15 | 7.78 ± 1.21 | 0.057 |
HbA1c (%) | 7.44 ± 1.06 | 7.44 ± 1.02 | 7.58 ± 1.10 | 7.62 ± 1.19 | 0.181 |
ApoB (mg/dL) | 83.10 (26.80) | 81.56 (23.96) | 84.48 (25.47) | 92.95 (31.95)abc | < 0.001 |
ApoA1 (mg/dL) | 150.70 (33.05) | 145.71 (48.11) | 142.05 (32.93)a | 140.50 (32.99)ab | 0.001 |
Total cholesterol (mmol/L) | 4.34 (1.42) | 4.32 (1.29) | 4.41 (1.19) | 4.64 (1.49)abc | < 0.001 |
Triglycerides (mmol/L) | 1.33 (0.82) | 1.28 (0.96) | 1.31 (0.95) | 1.36 (0.82) | 0.997 |
HDL-C (mmol/L) | 1.16 (0.41) | 1.13 (0.38) | 1.12 (0.27)a | 1.12 (0.35)a | 0.023 |
LDL-C (mmol/L) | 2.66 (1.00) | 2.69 (0.81) | 2.73 (0.85)a | 3.02 (1.17)abc | < 0.001 |
Lp(a) (nmol/L) | 30.67 (19.41) | 36.54 (26.13)a | 40.33 (35.36)a | 76.71 (84.78)abc | < 0.001 |
hs-CRP (mg/L) | 1.33 (1.62) | 1.51 (1.85) | 1.31 (1.79) | 1.34 (1.55) | 0.948 |
HCY (umol/L) | 11.21 (6.62) | 11.40 (7.14) | 11.33 (6.62) | 13.56 (9.80)abc | < 0.001 |
sdLDL-C (mmol/L) | 0.73 (0.43) | 0.69 (0.43) | 0.75 (0.35) | 0.79 ( 0.47)ab | 0.008 |
PCSK9 (ng/mL) | 379.84 (83.46) | 480.04 (47.30) | 566.52 (44.78) | 765.66 (200.58) | Â |