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Table 3 Use of glucose-lowering drugs in Mexico categorized by cardiovascular disease and in the overall study population

From: A cross-sectional study on the prevalence of cardiovascular disease in elderly patients with long-term type 2 diabetes mellitus mainly attended in private clinics in Mexico. The CAPTURE study

 

Study population N = 820

CVD status

Overall study population (n = 9823)

CVD n = 302

No CVD n = 518

Any glucose lowering drug

88.5%

86.8%

89.6%

96.6%

Any glucose lowering drug with proven CV benefit*

16.3%

9.6%

20.3%

21.9%

Oral glucose lowering drugs

 Biguanide

79.4%

76.8%

80.9%

75.6%

 DPP-4 inhibitor

21.6%

16.2%

24.7%

29.2%

 Sulfonylurea

26.3%

27.8%

25.5%

21.6%

 SGLT-2 inhibitor

15.5%

9.6%

18.9%

16.0%

 Alpha glucosidase inhibitor

1.3%

1.3%

1.4%

5.3%

 Thiazolidinedione

5.2%

5%

5.4%

3.8%

 Glinide

0

0

0

3.3%

 Others

0

0

0

0.3%

 Insulin

36.1%

39.1%

34.4%

37.7%

 GLP-1 receptor agonist (arGLP-1)

3.9%

1.0%

5.6%

10.1%

 Monotherapy

32.3%

36.8%

29.7%

30.0%

 Dual therapy†

46.5%

45.7%

46.9%

36.3%

 Triple therapy†

15.9%

14.2%

16.8%

22.3%

 Treatment with ≥ 4 glucose lowering drugs

4%

1.3%

5.6%

8.0%

  1. insulin, biguanide and sulfonylurea and insulin, biguanide and DPP-4 inhibitor and SGLT-2 inhibitor. †Reported in ≥ 1.0% of the total population of the CAPTURE study, group with CVD or group without CVD; * defined per 2020 American Diabetes Association guidelines as GLP-1 RAs: dulaglutide, liraglutide, and semaglutide; and SGLT2is: canagliflozin, dapagliflozin, and empagliflozin
  2. CVD cardiovascular disease, iDPP-4 dipeptidyl peptidase 4 inhibitor, arGLP-1 RA receptor agonist of the peptide similar to type 1 glucagon, iSGLT-2 type 2 sodium-glucose co-transporter inhibitor
  3. Monotherapy included any of the following drugs: biguanide, insulin, DPP-4 inhibitor, sulfonylurea, SGLT-2 inhibitor or GLP-1 receptor agonist; Dual therapy included any of the following combinations: biguanide and insulin (either), biguanide and DPP-4 inhibitor, biguanide and sulfonylurea, biguanide and SGLT-2 inhibitor, biguanide and arGLP-1, SGLT-2 inhibitor and insulin; Triple therapy included any of the following combinations: biguanide and sulfonylurea and DPP-4 inhibitor, biguanide and DPP-4 inhibitor and insulin (any), biguanide and arGLP-1 and insulin, biguanide and SGLT-2 inhibitor and