|  |  | All-cause mortality |  |  | Cardiovascular mortality |  |
---|---|---|---|---|---|---|---|
Subgroup | Total | Event(%) | HR(95%CI) | P for interaction | Event(%) | HR(95%CI) | P for interaction |
Gender = Female |  |  |  | 0.726 |  |  | 0.115 |
 LTL Tertile3 | 373 | 101 (27.1) | 1(Ref) |  | 19 (5.1) | 1(Ref) |  |
 LTL Tertile2 | 329 | 120 (36.5) | 1.01 (0.77 ~ 1.33) |  | 32 (9.7) | 1.46 (0.81 ~ 2.62) |  |
 LTL Tertile1 | 307 | 162 (52.8) | 1.19 (0.92 ~ 1.55) |  | 47 (15.3) | 1.61 (0.92 ~ 2.81) |  |
Trend test | 1009 | 383 (38) | 1.1 (0.96 ~ 1.25) |  | 98 (9.7) | 1.24 (0.95 ~ 1.62) |  |
Gender = Male |  |  |  |  |  |  |  |
 LTL Tertile3 | 287 | 94 (32.8) | 1(Ref) |  | 33 (11.5) | 1(Ref) |  |
 LTL Tertile2 | 331 | 125 (37.8) | 0.91 (0.69 ~ 1.19) |  | 39 (11.8) | 0.82 (0.51 ~ 1.31) |  |
 LTL Tertile1 | 353 | 217 (61.5) | 1.16 (0.9 ~ 1.5) |  | 61 (17.3) | 0.91 (0.58 ~ 1.41) |  |
Trend test | 971 | 436 (44.9) | 1.1 (0.97 ~ 1.25) |  | 133 (13.7) | 0.97 (0.77 ~ 1.21) |  |
Chronic kidney disease = no | 0.659 |  |  | 0.403 | |||
 LTL Tertile3 | 537 | 128 (23.8) | 1(Ref) |  | 33 (6.1) | 1(Ref) |  |
 LTL Tertile2 | 491 | 145 (29.5) | 0.92 (0.72 ~ 1.17) |  | 37 (7.5) | 0.86 (0.53 ~ 1.39) |  |
 LTL Tertile1 | 435 | 197 (45.3) | 1.15 (0.91 ~ 1.45) |  | 54 (12.4) | 1.09 (0.69 ~ 1.72) |  |
Trend test | 1463 | 470 (32.1) | 1.08 (0.96 ~ 1.22) |  | 124 (8.5) | 1.06 (0.84 ~ 1.34) |  |
Chronic kidney disease = yes |  |  |  |  | |||
 LTL Tertile3 | 123 | 67 (54.5) | 1(Ref) |  | 19 (15.4) | 1(Ref) |  |
 LTL Tertile2 | 169 | 100 (59.2) | 1.2 (0.87 ~ 1.65) |  | 34 (20.1) | 1.61 (0.89 ~ 2.91) |  |
 LTL Tertile1 | 225 | 182 (80.9) | 1.32 (0.98 ~ 1.79) |  | 54 (24) | 1.4 (0.8 ~ 2.44) |  |
Trend test | 517 | 349 (67.5) | 1.14 (0.99 ~ 1.32) |  | 107 (20.7) | 1.12 (0.87 ~ 1.45) |  |
Corory heart disease = no | 0.351 |  |  | 0.695 | |||
 LTL Tertile3 | 631 | 174 (27.6) | 1(Ref) |  | 43 (6.8) | 1(Ref) |  |
 LTL Tertile2 | 623 | 222 (35.6) | 1 (0.82 ~ 1.22) |  | 59 (9.5) | 1.07 (0.71 ~ 1.59) |  |
 LTL Tertile1 | 619 | 346 (55.9) | 1.24 (1.02 ~ 1.49) |  | 91 (14.7) | 1.21 (0.83 ~ 1.77) |  |
Trend test | 1873 | 742 (39.6) | 1.12 (1.02 ~ 1.24) |  | 193 (10.3) | 1.11 (0.92 ~ 1.33) |  |
Corory heart disease = yes |  |  |  |  |  | ||
 LTL Tertile3 | 29 | 21 (72.4) | 1(Ref) |  | 9 (31) | 1(Ref) |  |
 LTL Tertile2 | 37 | 23 (62.2) | 0.69 (0.36 ~ 1.32) |  | 12 (32.4) | 0.85 (0.34 ~ 2.14) |  |
 LTL Tertile1 | 41 | 33 (80.5) | 1.12 (0.62 ~ 2.03) |  | 17 (41.5) | 1.39 (0.58 ~ 3.33) |  |
Trend test | 107 | 77 (72) | 1.07 (0.79 ~ 1.47) |  | 38 (35.5) | 1.21 (0.77 ~ 1.91) |  |
DM = yes |  |  |  | 0.207 |  |  | 0.241 |
 LTL Tertile3 | 126 | 66 (52.4) | 1(Ref) |  | 24 (19) | 1(Ref) |  |
 LTL Tertile2 | 150 | 74 (49.3) | 0.87 (0.62 ~ 1.23) |  | 21 (14) | 0.71 (0.39 ~ 1.3) |  |
 LTL Tertile1 | 160 | 113 (70.6) | 1.02 (0.74 ~ 1.41) |  | 37 (23.1) | 0.98 (0.57 ~ 1.7) |  |
Trend test | 436 | 253 (58) | 1.02 (0.87 ~ 1.2) |  | 82 (18.8) | 1.01 (0.76 ~ 1.34) |  |
DM = no |  |  |  |  |  |  |  |
 LTL Tertile3 | 477 | 126 (26.4) | 1(Ref) |  | 28 (5.9) | 1(Ref) |  |
 LTL Tertile2 | 483 | 169 (35) | 0.98 (0.78 ~ 1.24) |  | 50 (10.4) | 1.23 (0.77 ~ 1.97) |  |
 LTL Tertile1 | 489 | 266 (54.4) | 1.25 (1 ~ 1.56) |  | 71 (14.5) | 1.33 (0.84 ~ 2.1) |  |
Trend test | 1449 | 561 (38.7) | 1.13 (1.02 ~ 1.27) |  | 149 (10.3) | 1.14 (0.92 ~ 1.42) |  |
Hypertension = no |  |  | 0.846 |  |  | 0.689 | |
 LTL Tertile3 | 235 | 43 (18.3) | 1(Ref) |  | 10 (4.3) | 1(Ref) |  |
 LTL Tertile2 | 201 | 42 (20.9) | 0.88 (0.57 ~ 1.37) |  | 10 (5) | 0.99 (0.4 ~ 2.46) |  |
 LTL Tertile1 | 165 | 63 (38.2) | 1.12 (0.75 ~ 1.7) |  | 12 (7.3) | 0.96 (0.39 ~ 2.37) |  |
Trend test | 601 | 148 (24.6) | 1.07 (0.87 ~ 1.32) |  | 32 (5.3) | 0.98 (0.63 ~ 1.54) |  |
Hypertension = yes |  |  |  |  |  |  | |
 LTL Tertile3 | 425 | 152 (35.8) | 1(Ref) |  | 42 (9.9) | 1(Ref) |  |
 LTL Tertile2 | 459 | 203 (44.2) | 0.97 (0.78 ~ 1.2) |  | 61 (13.3) | 1.02 (0.68 ~ 1.52) |  |
 LTL Tertile1 | 495 | 316 (63.8) | 1.22 (1 ~ 1.5) |  | 96 (19.4) | 1.22 (0.84 ~ 1.78) |  |
Trend test | 1379 | 671 (48.7) | 1.12 (1.02 ~ 1.24) |  | 199 (14.4) | 1.12 (0.93 ~ 1.35) |  |
Hyperlipidemia = no |  |  | 0.857 |  |  | 0.987 | |
 LTL Tertile3 | 105 | 37 (35.2) | 1(Ref) |  | 10 (9.5) | 1(Ref) |  |
 LTL Tertile2 | 86 | 34 (39.5) | 0.83 (0.49 ~ 1.4) |  | 10 (11.6) | 1.06 (0.34 ~ 3.33) |  |
 LTL Tertile1 | 100 | 59 (59) | 1.24 (0.79 ~ 1.96) |  | 15 (15) | 1.18 (0.42 ~ 3.31) |  |
Trend test | 291 | 130 (44.7) | 1.15 (0.91 ~ 1.45) |  | 35 (12) | 1.09 (0.66 ~ 1.8) |  |
Hyperlipidemia = yes |  |  |  |  |  |  | |
 LTL Tertile3 | 555 | 158 (28.5) | 1(Ref) |  | 42 (7.6) | 1(Ref) |  |
 LTL Tertile2 | 574 | 211 (36.8) | 0.97 (0.78 ~ 1.19) |  | 61 (10.6) | 1 (0.67 ~ 1.49) |  |
 LTL Tertile1 | 560 | 320 (57.1) | 1.17 (0.96 ~ 1.43) |  | 93 (16.6) | 1.16 (0.79 ~ 1.7) |  |
Trend test | 1689 | 689 (40.8) | 1.1 (0.99 ~ 1.21) |  | 196 (11.6) | 1.09 (0.9 ~ 1.31) |  |
Stroke = no |  |  |  | 0.655 |  |  | 0.218 |
LTL Tertile3 | 644 | 183 (28.4) | 1(Ref) | Â | 46 (7.1) | 1(Ref) | Â |
LTL Tertile2 | 632 | 226 (35.8) | 0.97 (0.8 ~ 1.18) |  | 67 (10.6) | 1.11 (0.76 ~ 1.62) |  |
LTL Tertile1 | 629 | 351 (55.8) | 1.18 (0.98 ~ 1.42) |  | 100 (15.9) | 1.21 (0.84 ~ 1.73) |  |
Trend test | 1905 | 760 (39.9) | 1.1 (1 ~ 1.21) |  | 213 (11.2) | 1.1 (0.92 ~ 1.31) |  |
Stroke = yes |  |  |  |  |  |  |  |
 LTL Tertile3 | 16 | 12 (75) | 1(Ref) |  | 6 (37.5) | 1(Ref) |  |
 LTL Tertile2 | 28 | 19 (67.9) | 0.91 (0.32 ~ 2.52) |  | 4 (14.3) | 0.41 (0.04 ~ 4.26) |  |
 LTL Tertile1 | 31 | 28 (90.3) | 1.74 (0.66 ~ 4.58) |  | 8 (25.8) | 1.33 (0.22 ~ 8.09) |  |
Trend test | 75 | 59 (78.7) | 1.46 (0.93 ~ 2.31) |  | 18 (24) | 1.32 (0.53 ~ 3.26) |  |
Cancer = no |  |  |  | 0.425 |  |  | 0.138 |
 LTL Tertile3 | 598 | 164 (27.4) | 1(Ref) |  | 44 (7.4) | 1(Ref) |  |
 LTL Tertile2 | 582 | 199 (34.2) | 0.91 (0.74 ~ 1.13) |  | 55 (9.5) | 0.86 (0.57 ~ 1.29) |  |
 LTL Tertile1 | 561 | 300 (53.5) | 1.14 (0.93 ~ 1.39) |  | 89 (15.9) | 1.12 (0.77 ~ 1.64) |  |
Trend test | 1741 | 663 (38.1) | 1.08 (0.98 ~ 1.2) |  | 188 (10.8) | 1.09 (0.9 ~ 1.32) |  |
Cancer = yes |  |  |  |  |  |  |  |
 LTL Tertile3 | 62 | 31 (50) | 1(Ref) |  | 8 (12.9) | 1(Ref) |  |
 LTL Tertile2 | 78 | 46 (59) | 1.21 (0.75 ~ 1.97) |  | 16 (20.5) | 1.75 (0.69 ~ 4.42) |  |
 LTL Tertile1 | 99 | 79 (79.8) | 1.49 (0.95 ~ 2.33) |  | 19 (19.2) | 1.53 (0.62 ~ 3.78) |  |
Trend test | 239 | 156 (65.3) | 1.22 (0.98 ~ 1.52) |  | 43 (18) | 1.18 (0.77 ~ 1.81) |  |