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Table 2 Survey-weighted cox proportional hazard results examining the association of SIRI with all-cause and cardiovascular disease mortality in the obese population. (SIRI was divided into quartiles, with the lowest group as the reference group)

From: System inflammation response index: a novel inflammatory indicator to predict all-cause and cardiovascular disease mortality in the obese population

 

Death

Adjusted model 1

Adjusted model 2

Adjusted model 3

Adjusted model 4

Adjusted model 5

Adjusted model 6

 

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

 

1959

All-cause mortality

Q1

341

Reference

Reference

Reference

Reference

Reference

Reference

Q2

403

1.06 (0.89–1.26)c

1.06 (0.88–1.29)c

0.99 (0.79–1.23)c

0.97 (0.78–1.19)c

0.97 (0.79–1.18)c

0.95 (0.77–1.16)c

Q3

489

1.22 (1.02–1.46) a

1.13 (1.05–1.21)a

1.18 (0.93–1.49)c

1.10 (0.88–1.38)c

1.08 (0.87–1.34)c

1.01 (0.82–1.25)c

Q4

726

1.81 (1.52–2.14)b

2.09 (1.73–2.53)b

1.66 (1.35–2.04)b

1.47 (1.20–1.81)b

1.43 (1.18–1.75)b

1.30 (1.07–1.58)a

P for trend

 

 < 0.001

 < 0.001

 < 0.001

 < 0.001

 < 0.001

 < 0.001

Per SD increase

 

1.23 (1.16–1.31)b

1.27 (1.22–1.34)b

1.20 (1.15–1.26)b

1.18 (1.13–1.24)b

1.18 (1.11–1.25)b

1.16 (1.09–1.23)b

 

553

Cardiovascular disease mortality

Q1

90

Reference

Reference

Reference

Reference

Reference

Reference

Q2

93

0.91 (0.66–1.27)c

0.89 (0.62–1.29)c

0.88 (0.58–1.34)c

0.83 (0.55–1.27)c

0.83 (0.55–1.26)c

0.87 (0.57–1.33)c

Q3

131

1.17 (0.86–1.58)c

1.14 (0.81–1.59)c

1.09 (0.73–1.62)c

0.98 (0.66–1.48)c

0.96 (0.64–1.42)c

0.88 (0.59–1.30)c

Q4

239

2.16 (1.55–3.01)b

2.02 (1.41–2.88)b

1.99 (1.32–2.99)a

1.70 (1.12–2.59)a

1.62 (1.08–2.42)a

1.57 (1.05–2.37)a

P for trend

 

 < 0.001

 < 0.001

 < 0.001

 < 0.001

0.002

0.004

Per SD increase

 

1.28 (1.18–1.39)b

1.33 (1.24–1.41)b

1.25 (1.16–1.34)b

1.24 (1.14–1.34)b

1.22 (1.11–1.35)b

1.22 (1.10–1.36)b

  1. Model 1 adjust age
  2. Model 2 adjust Model 1 plus other demographic variables including sex, race, education levels and poverty income ratio
  3. Model 3 adjusted Model 2 plus other parameters including body mass index, estimated glomerular filtration rate, alanine aminotransferase, total cholesterol, and high-density lipoprotein cholesterol
  4. Model 4 adjusted Model 3 plus history of diseases including cardiovascular diseases, diabetes mellitus, hypertension, and hyperlipidemia
  5. Model 5 adjusted Model 4 plus medication including antihypertensives, glucose-lowering and lipid-lowering drugs
  6. Model 6 adjusted Model 5 plus lifestyle variables including smoking and drinking
  7. aIndicates p-value < 0.05
  8. bIndicates p-value < 0.001
  9. cIndicates p-value ≥ 0.05