Association of N-terminal pro-B-type natriuretic peptide levels and mortality risk in acute myocardial infarction across body mass index categories: an observational cohort study

Table 2 Univariable and multivariable Cox regression analysis for all-cause mortality

Variables	Univariable model			Multivariable model
Variables	HR	95% CI	P value	HR	95% CI	P value
Female	1.81	1.56–2.10	< 0.001	0.81	0.68–0.96	0.016
Ln NT-proBNP, per 1-SD	3.46	3.14–3.80	< 0.001	1.82	1.60–2.07	< 0.001
Long-term GRACE risk score, per decile	1.56	1.51–1.62	< 0.001	1.31	1.25–1.37	< 0.001
LVEF, per 5%	0.78	0.75–0.80	< 0.001	0.95	0.92–0.99	0.011
BMI, per 1 kg/m²	0.87	0.86–0.89	< 0.001	0.97	0.95–0.99	0.015
Hypertension	1.51	1.28–1.78	< 0.001
Diabetes mellitus	1.50	1.29–1.74	< 0.001	1.19	1.01–1.40	0.034
Ln hs-CRP, per unit	1.37	1.28–1.46	< 0.001
Ln peak value of hs-TnI, per unit	0.98	0.95–1.02	0.354
Aspirin	0.14	0.12–0.17	< 0.001	0.48	0.38–0.60	< 0.001
Clopidogrel/Ticagrelor	0.25	0.22–0.29	< 0.001	0.79	0.64–0.97	0.025
ACEI/ARB	0.45	0.39–0.53	< 0.001
β-blocker	0.43	0.37–0.50	< 0.001
Statins	0.23	0.20–0.27	< 0.001	0.65	0.52–0.81	< 0.001
Diuretics	2.52	2.13–2.99	< 0.001

ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; BMI, body mass index; CI, confidence interval; GRACE, Global Registry of Acute Coronary Events; HR, hazard ratio; hs-CRP, high sensitivity C-reactive protein; hs-TnI, high sensitivity troponin I; LVEF, left ventricular ejection fraction; NT-proBNP, N-terminal pro-B-type natriuretic peptide

ISSN: 1758-5996