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Table 2 The risk of all-cause mortality, CVD mortality, and cancer mortality, according to FPG trajectory groups and baseline FPG groups

From: 6-Year trajectory of fasting plasma glucose (FPG) and mortality risk among individuals with normal FPG at baseline: a prospective cohort study

 

Cases

Total

Model 1 HR (95% CI)

Model 2 HR (95% CI)

FBG trajectory groups

 All-cause mortality

    

  Stable

419

32,481

Reference

Reference

  Low-increasing

397

17,164

2.02 (1.76, 2.32)***

1.18 (0.99, 1.41)

  High-increasing

61

1274

3.96 (3.03, 5.18)***

1.52 (1.09, 2.13)*

 CVD mortality

  

  Stable

68

32,481

Reference

Reference

  Low-increasing

70

17,164

2.19 (1.57, 3.06)***

1.28 (0.85, 1.95)

  High-increasing

13

1274

5.18 (2.86, 9.37)***

2.13 (1.00, 4.54)*

 Cancer mortality

  

  Stable

201

32,228

Reference

Reference

  Low-increasing

169

16,950

1.80 (1.47, 2.21)***

1.01 (0.78, 1.31)

  High-increasing

24

1260

3.28 (2.15, 5.00)***

1.10 (0.65, 1.86)

Baseline FPG group

 All-cause mortalitya

    

  FPG < 5.44 mmol/L

455

32,664

Reference

Reference

  FPG ≥ 5.44 and < 6.33 mmol/L

371

16,931

1.71 (1.49, 1.96)***

0.99 (0.78, 1.25)

  FPG ≥ 6.33 mmol/L

51

1,324

3.02 (2.26, 4.04)***

1.02 (0.61, 1.69)

Excluding individuals followed < 3 years

 All-cause mortality

    

  Stable

346

26,943

Reference

Reference

  Low-increasing

321

13,357

2.02 (1.74, 2.35)***

1.14 (0.94, 1.38)

  High-increasing

53

992

4.21 (3.15, 5.62)***

1.50 (1.04, 2.17)*

Using five FPG examinations in a 6-year period after baseline

 All-cause mortality

    

  Stable

161

14,034

Reference

Reference

  Low-increasing

200

9550

2.02 (1.64, 2.49)***

1.44 (1.12, 1.86)**

  High-increasing

43

1048

3.96 (2.83, 5.54)***

1.91 (1.22, 2.98)**

  1. Model 1: crude model
  2. Model 2: adjusted for age, sex, BMI, marital status, education level, smoking status, drinking status, physical activity, baseline FPG, hypertension, dyslipidemia, self-reported cancer at baseline, self-reported cardiovascular disease at baseline. Significance levels: *P < 0.05, **P < 0.01, ***P < 0.001
  3. a: the number of individuals in each FPG group corresponds to the percentage of individuals in each FPG trajectory group