Table 2 Animal experiment and cell experiment of insulin resistance-related microRNA changes after obesity
From: Biomarkers of obesity-mediated insulin resistance: focus on microRNAs
Range | Study | Population | Source | Regulated microRNAs | Target |
|---|---|---|---|---|---|
Obesity–inflammation–IR | Liu et al. [74] | HFD C57BL6 mice NCD lean mice | ATMs-derived exosome Serum | miR-29a (↑) | PPAR-β |
Zhang et al. [75] | Diabetic C57BL6 mice T3-L1 adipocytes cell Mouse macrophage cell | ATMs | miR-17 (↓) | ASK1 | |
Sun et al. [76] | HFD C57BL/6 mice LFD C57BL/6 mice | ATMs | miR-330-5p (↑) | Tim-3 | |
Hu et al. [77] | HFD C57BL6 mice NCD C57BL6 mice | ATMs | miR-495 (↑) | FTO | |
Ying et al. [78] | HFD C57BL6 mice | M2-polarized bone marrow-derived macrophages secrete miRNA- containing exosomes | miR-690 (↑) | Nadk | |
Koh et al. [79] | HFD DIO mice NCD C57BL/6J mice | Subcutaneous white adipose tissue | miR-30a (↓) | STAT1 | |
Roos et al. [80] | HFD miR-146a−/− mice ND miR-146a−/− mice | White adipose tissue | miR-146a (↓) | NPR3 | |
Wang et al. [81] | HFD C57BL/6 mice NCD C57BL/6 mice | Natural killer derived exosomes | miR-1249-3p (↓) | SKOR1-SMAD6-TLR4-NF-κB | |
Obesity–liver–IR | Song et al. [82] | HFD C57BL/6 mice NCD C57BL/6 mice | Liver tissue | miR-592 (↓) | FOXO1, glucose, and lipid metabolism |
Seok et al. [83] | HFD SHP-KO mice NCD FXR-KO mice | Hepatocytes Liver tissue | miR-802 (↑) | FXR-SHP-miR-802 | |
Yang et al. [84] | HFD C57BL/6 mice NCD C57BL/6 mice | Liver tissue | miR-107 (↑) | P53/PANK1/miR-107 | |
Price et al. [85] | HFD miR-133−/− mice ND miR-133−/− mice | Plasma Liver tissue | miR-33 (↓) | Lipid metabolism | |
Dai et al. [88] | HFD SD rats NCD SD rats | Liver tissue | miR-30b (↑) | SERCA2b, endoplasmic reticulum stress | |
Min et al. [89] | HFD C57BL/6N mice NFD C57BL/6N mice PA treated HepG2 cells | Plasma Liver tissue | miR-424-5p (↑) | INSR, insulin signaling and glycogen synthesis | |
Du et al. [90] | HFD C57BL/6N mice NFD C57BL/6N mice 10 MAO 10 Control | Liver tissue | miR-125b (↑) | PIK3CD and glucose metabolism | |
Obesity– Skeletal muscle–IR | Yu et al. [91] | 45 children with obesity 45 control children HFD C57BL/6N mice LFD C57BL/6N mice Db/Db mice Db/m mice | Serum Adipose tissue-derived exosomes | miR-27a (↑) | PPAR-γ |
Chen et al. [92] | HFD C57BL/6N mice NFD C57BL/6N mice 3T3-L1 cell | Pancreas Liver White adipose tissue | miR-27a (↑) | PPARγ-PI3K/AKT-GLUT4 | |
Obesity—Islets of langerhans β cell–IR | Zhang et al. [93] | HFD C57BL/6J mice NCD C57BL/6J mice | Islets | miR-802-5p (↑) | NeuroD1 and Fzd5, β cell dysfunction |
Wen et al. [94] | 3T3-L1 preadipocytes Cardiac myocytes | Hypertrophic adipocyte-derived exosomes | miR-802-5p (↑) | HSP60 | |
Xu et al. [95] | HFD C57BL/6J mice NCD C57BL/6J mice | Brown preadipocytes Serum exosomes Islets | miR-26a (↓) | β cell hyperplasia | |
Obesity–Gut microbiota–IR | Virtue et al. [96] | HFD C57BL/6 mice NCD C57BL/6 mice | Epididymal white adipose tissue Plasma Feces | miR-181 (↑) | Tryptophan derivatives |