Table 1 Clinical research on the changes of microRNA associated with insulin resistance after obesity
From: Biomarkers of obesity-mediated insulin resistance: focus on microRNAs
Range | Study | Population/age groups | Source | Regulated microRNAs | Role/target |
|---|---|---|---|---|---|
Direct comparative study between MAO and MHO individuals | Fayaz et al. [62] | 18 MHO 21 MAO Adults (18–65 years) | Serum | miR-331-3p, miR-452-3p, miR- 485-5p (↑) miR-153-3p, miR-182-5p, miR-4333p(↓) | Biomarkers of HbA1c/IGF1R |
Ghorbani et al. [63] | 45 MAO 42 MHO Adults (40–65 years) | Serum | miR-21 (↓) | Biomarkers of obesity-mediated T2D | |
Zhang et al. [64] | 45 MHO 52 MAO 50 controls Children and adolescents (1–17 years) | Plasma | miR-24-3p (↑) | Biomarkers of metabolic syndrome in children with obesity | |
Pan et al. [65] | 36 control 36 obese 12 T2D Adults (18–65 years) | Serum | miR-4431 (↑) | Biomarkers of obesity-related glucose metabolism/TRIP10 and PRKD1 | |
Cerda et al. [66] | 6 MAO 6 MHO Adults (18–65 years) | Plasma | miR-155 (↓) | Biomarkers of obesity-related IR and high cardiac metabolic risk/CEBPB | |
Lin et al. [67] | 7 MHO 8 IR 16 NAFLD Adolescents (10–17 years) | Serum | miR-21-5p, miR-22-3p, miR-150-5p, miR-155-5p, miR-27-3a (↑) | Biomarkers of IR and nonalcoholic fatty liver risk in patients with obesity | |
Direct comparative study between MAO and healthy individuals | Lin et al. [68] | 50 MAO 50 control Adults (40–65 years) | Serum and urine | miR-143-3p (↑) | Biomarkers of obesity-related IR/IGF2R and IGFBP5 |
Lin et al. [69] | 33 obese Adolescents (10–17 years) | Plasma | miR-30d, miR-221, miR-122 (↑) | Target: Increased levels of miR-30d, miR-221, and miR-122 are associated with obesity-associated IR | |
Herrero-Aguayo et al. [70] | Cohort A: 8 male (4 control, 4 obese) Cohort B: 221 male (80 control, 62 obese, 79 overweight) Cohort C: 18 male (10 control, 8 obese) Adults (18–65 years) | Plasma | miR-4454 (↑) | Biomarkers of obesity-related IR and HOMA-index/spliceosome pathway, Akt, AMPK, and ERK | |
Arcidiacono et al. [71] | 26 MHO 20 control Adults (18–65 years) | Omental visceral adipose tissue, plasma | miR-128 (↑) | Target: Increased miR-128 content correlates with INSR mRNA and protein expression in VAT | |
Lozano-Bartolomé et al. [72] | Cohort A:58 obese (28 BMI < 30 kg/m2, 30 BMI > 30 kg/m2) Cohort B: 101 patients (53 control, 48 obese) Adults (18–65 years) | Adipose tissue, plasma | miR-181a-5p (↓) | Biomarkers of obesity-related insulin resistance/PTEN | |
Doumatey et al. [73] | Cohort A:10 MAO, 10 MHO Cohort B:64 MHO, 34 MAO Adults (18–65 years) | Serum | miR-374a-5p (↓) | Target: Decreased miR-374a-5p levels are associated with CCL2 and involved in obesity-associated inflammatory responses |