Fig. 1
From: Biomarkers of obesity-mediated insulin resistance: focus on microRNAs
Complications caused by obesity. Obesity is a risk factor for many diseases, such as atherosclerosis, cardiovascular disease, insulin resistance, type 2 diabetes, hypogonadism, chronic inflammation, non-alcoholic fatty liver disease, osteoporosis, etc. There is an interrelationship between these complications. Obesity leads to chronic inflammation and disorders of lipid metabolism, where chronic inflammation is an intermediate factor leading to insulin resistance. Lipid metabolism disorder is an intermediate factor leading to atherosclerosis, while chronic inflammation will further lead to the development of atherosclerosis to coronary heart disease. In addition to this, chronic inflammation interacts with lipid metabolism disorders and both together lead to osteoporosis, hypogonadism and non-alcoholic fatty liver disease