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Table 2 Association analysis of selected SDC4 SNPs with Metabolic Syndrome

From: Syndecan-4 as a genetic determinant of the metabolic syndrome

SNP ID

Position (GRCh38.p14)

Genomic Location

MAF

OR (95% CI)a,b

p-values

rs2228384-T/C

45,348,351

Exon 1 (F-L)

0.45

0.34 (0.15–0.78)R

0.007

rs2072785-G/T

45,347,894

Intron 1

0.45

0.36 (0.16–0.79)R

0.007

rs1981429-T/G

45,347,053

Intron 1

0.40

1.83 (1.06–3.14)D

0.027

rs2267871-A/T

45,343,730

Intron 1

0.31

1.30 (0.63–2.70)R

0.480

rs2251252-G/A

45,342,717

Intron 1

0.49

0.59 (0.33–1.05)D

0.071

rs2284277-G/A

45,338,670

Intron 1

0.22

0.87 (0.50–1.51)D

0.610

rs6130811-C/G

45,334,849

Intron 2

0.33

0.49 (0.17–1.41)R

0.170

rs2070639-T/G

45,330,210

Intron 4

0.47

1.53 (0.82–2.85)R

0.180

rs4599-A/G

45,325,767

3’UTR

0.21

0.71 (0.212.42)R

0.570

rs749111-A/T

45,322,906

3’ near gene

0.15

1.44 (0.81–2.55)D

0.210

rs11697824-G/A

45,322,360

3’ near gene

0.17

0.74 (0.40–1.34)D

0.320

  1. Abbreviations: MAF: Minor Allele Frequency in our control group; OR: odds ratio; CI: confidence interval
  2. a Logistic regression OR adjusted for age and sex
  3. bFor each SNP the best model was considered: R recessive, D dominant
  4. Significant p-values (< 0.05) are highlighted in bold