Fig. 2

Sex-dependent alterations in cardiometabolic risk parameters of Sdc4 deficient mice fed a 14-week LFD. (A-D) Following the dietary intervention, male Sdc4^−/− mice had lower total cholesterol (panel A), but female Sdc4^−/− mice had higher levels of fasting TG (panel B), reduced glucose tolerance (panel C), and lower whole-body insulin sensitivity index (panel D) than their corresponding WT mice. In panels A, B, and D, box and whiskers plots denote individual data points separated by a line representing the group median. Each individual value is plotted as a dot superimposed on the boxplots. In panel C, data indicate mean ± SE of glucose during the OGTT (left) and total area under the curve (AUC) (right) for n = 6–7 independent replicates. In all panels, **p < 0.01 and ***p < 0.001, obtained from Tukey post hoc tests for multiple comparisons