Exercise mitigates Dapagliflozin-induced skeletal muscle atrophy in STZ-induced diabetic rats

Table 1 Comparisons of body weight, subcutaneous fat weight and muscle weight in each group

	CON	DAPA	DAPA + AE	DAPA + RT
Initial BW (g)	480 ± 5.30	481 ± 6.30	483 ± 4.90	480 ± 7.80
Final BW (g)	601 ± 6.50	581 ± 9.60*	577 ± 5.60*	589 ± 11.70*
Change in body weight (g)	121 ± 12.80	102 ± 33.30*	94 ± 23.90**	104.5 ± 32.10*
Subcutaneous fat weight (g)	2.16 ± 0.42	1.53 ± 0.25**	1.43 ± 0.19***	1.55 ± 0.21**
Sol muscle weight (mg)	342.50 ± 10.70	332.50 ± 8.04	335.00 ± 8.16	335.83 ± 9.32
FHL muscle weight (mg)	516.67 ± 25.11	492.50 ± 40.08	507.50 ± 27.80	544.16 ± 37.46
Gas muscle weight (mg)	3155.00 ± 72.86	3039.17 ± 67.42	3065.00 ± 59.02	3104.58 ± 93.68
EDL muscle weight (mg)	285.37 ± 5.38^#	258.87 ± 10.47	267.63 ± 10.47	283.33 ± 17.04^#

The values are presented as means ± SEM. BW, body weight; Sol, soleus muscle; FHL, flexor hallucis longus muscle; Gas, gastrocnemius muscle; EDL, extensor digitorum longus muscle. Statistical difference from the CON group is denoted by (^*P < 0.05; ^**P < 0.01; ^***P < 0.001), while statistical difference from the DAPA group is denoted by (^#P < 0.05)

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