Fig. 4

Effects of ADSCs-Exo and high glucose treatment on Nrf2 pathway of podocytes

(A) WB was used to detect the effect of ADSCs-Exo and high glucose on Nrf2 expression in MPC5 cells, and GAPDH was used as an internal control. (B) IF was used to detect the effects of ADSCs-Exo and high glucose treatment on Nrf2 distribution in MPC5 nucleus; (C) WB was used to detect the effect of ADSCs-Exo on Nrf2 expression in kidney tissue of model mice, and GAPDH was used as an internal control. Data are presented as Mean ± SD and one-way analysis of variance was used to detect statistical differences between groups. Panel A. ns p > 0.05 VS. NG; ** p < 0.01 VS. NG; ## p < 0.01VS. HG. Panel C.** p < 0.01 VS. db/m; # p < 0.05 VS. db/db. The scale in Panel B is 20 μm