Variable | Lean | ZDF | ZDF + Dapa |
---|---|---|---|
Metabolic characteristics | |||
 BW (g) | 344.8 ± 25.1 | 466.3 ± 31.6* | 419.8 ± 27.9# |
 HW (g) | 1.25 ± 0.12 | 1.37 ± 0.13 | 1.35 ± 0.13 |
 HW/BW (g/kg) | 3.32 ± 0.17 | 3.39 ± 0.19 | 3.25 ± 0.24 |
 HW/TL (g/cm) | 0.322 ± 0.014 | 0.353 ± 0.018* | 0.344 ± 0.017* |
 FBG (mmol/L) | 6.5 ± 0.8 | 18.4 ± 2.6* | 11.3 ± 1.7# |
 HbA1c (%) | 5.1 ± 0.9 | 15.8 ± 3.2* | 10.4 ± 2.7# |
 24 h urine glucose (mg/200 g BW) | 2.8 ± 0.5 | 275.4 ± 21.1* | 4790.4 ± 746.7# |
 Creatinine (mg/dl) | 0.72 ± 0.13 | 0.65 ± 0.15 | 0.63 ± 0.11 |
 ANP (pg/mL) | 82.4 ± 21.0 | 213.5 ± 56.3* | 188.2 ± 54.9* |
 NT-proBNP (pg/mL) | 253.5 ± 62.7 | 863.3 ± 127.5* | 475.2 ± 112.3# |
Echocardiographic parameters | |||
 LVIDs (mm) | 7.73 ± 0.58 | 7.74 ± 0.66 | 7.68 ± 0.67 |
 LVIDd (mm) | 11.87 ± 0.67 | 11.74 ± 0.71 | 11.61 ± 0.78 |
 LVAWs (mm) | 2.30 ± 0.15 | 2.71 ± 0.17* | 2.46 ± 0.12# |
 LVAWd (mm) | 1.59 ± 0.09 | 1.75 ± 0.07* | 1.70 ± 0.05 |
 LVPWs (mm) | 2.49 ± 0.11 | 2.64 ± 0.15 | 2.67 ± 0.13 |
 LVPWd (mm) | 1.74 ± 0.09 | 1.86 ± 0.11* | 1.77 ± 0.09 |
 RWT | 0.41 ± 0.03 | 0.45 ± 0.05 | 0.43 ± 0.05 |
 LVmass (g) | 0.90 ± 0.03 | 0.95 ± 0.05 | 0.96 ± 0.06 |
 LVmass/TL (g/cm) | 0.22 ± 0.01 | 0.27 ± 0.02* | 0.24 ± 0.01 |
 LVmass index (g/kg) | 2.38 ± 0.18 | 2.79 ± 0.22* | 2.68 ± 0.20 |
 IVSd (mm) | 2.59 ± 0.13 | 2.76 ± 0.15 | 2.70 ± 0.13 |
 E/e' | 2.17 ± 0.18 | 2.31 ± 0.19* | 2.26 ± 0.21# |
 E/A | 1.71 ± 0.12 | 1.63 ± 0.12* | 1.65 ± 0.11 |
 DT (ms) | 62.1 ± 10.1 | 76.8 ± 11.9* | 75.6 ± 10.6 |
 IVRT (ms) | 31.2 ± 1.6 | 34.9 ± 1.9* | 32.6 ± 1.3# |
Haemodynamic parameters | |||
 HR (bpm) | 321 ± 19 | 328 ± 17 | 330 ± 16 |
 MAP (mmHg) | 95 ± 8 | 106 ± 11* | 98 ± 7# |
 EF (%) | 76.9 ± 3.3 | 74.8 ± 2.7 | 77.9 ± 3.7 |
 CO (mL/min) | 70 ± 6 | 68 ± 7 | 70 ± 6 |
 dP/dtmax (mmHg/s) | 4042 ± 324 | 3881 ± 202 | 4167 ± 263 |
 dP/dtmin (mmHg/s) | − 3366 ± 252 | − 2857 ± 194* | − 3095 ± 271# |