Fig. 7From: Therapeutic effects on the development of heart failure with preserved ejection fraction by the sodium-glucose cotransporter 2 inhibitor dapagliflozin in type 2 diabetesProteomics deciphered the changes in the treated T2DM individuals with HFpEF. a Summary of differentially expressed proteins for each pairwise comparison. b Venn diagram showing the relationship between three pairwise comparisons. c Heatmap for protein detection from the proteomics data. Each column represents a protein marker, and each row represents a loading sample of the DM-HF and the DAPA group. d Volcano plots of the proteomics data for the pairwise comparison. Up-regulated and down-regulated proteins are marked with red and blue colors, respectively. e KEGG pathway enrichment and f GO term analyses. g The interaction relationship of differentially expressed proteins was obtained from the STRING database (https://string-db.org/), and the top 25 proteins were selected to draw the interaction network diagram. Red represents up-regulated genes, and the green represents down-regulated genes. The size of the circle represents the degree of connectivityBack to article page