| Unadjusted model | Adjusted model | ||
---|---|---|---|---|
 | Estimate(95%CI) | P-value | Estimate(95%CI) | P-value |
Binary scale, HUA (vs. Non-HUA) | Â | Â | Â | Â |
 Total Effect (OR) | 1.609(1.295–1.923) | < 0.001 | 2.030(1.530–2.530) | < 0.001 |
 Natural Direct Effect (OR) | 1.324(1.079–1.569) | 0.010 | 1.578(1.209–1.948) | 0.002 |
 Natural Indirect Effect (OR) | 1.215(1.137–1.294) | < 0.001 | 1.287(1.183–1.391) | < 0.001 |
 Percentage Mediated (%) | 46.80(29.80–63.79) | < 0.001 | 43.89(30.38–57.40) | < 0.001 |
Continuous scale, Per SD in UA | Â | Â | Â | Â |
 Total Effect (OR) | 1.274(1.187–1.361) | < 0.001 | 1.485(1.352–1.618) | < 0.001 |
 Natural Direct Effect (OR) | 1.127(1.053–1.200) | < 0.001 | 1.268(1.159–1.377) | < 0.001 |
 Natural Indirect Effect (OR) | 1.131(1.103–1.159) | < 0.001 | 1.171(1.133–1.210) | < 0.001 |
 Percentage Mediated (%) | 53.76(39.56–67.96) | < 0.001 | 44.77(34.71–54.84) | < 0.001 |
Binary scale, HHCY (vs. Non-HHCY) | Â | Â | Â | Â |
 Total Effect (OR) | 1.023(0.885–1.160) | 0.747 | 1.339(1.101–1.577) | 0.005 |
 Natural Direct Effect (OR) | 0.975(0.851–1.099) | 0.688 | 1.212(1.008–1.416) | 0.042 |
 Natural Indirect Effect (OR) | 1.049(1.003–1.096) | 0.038 | 1.104(1.041–1.168) | 0.001 |
 Percentage Mediated (%) | 211.93(-997.27–1421.13) | 0.731 | 37.34(13.86–60.83) | 0.002 |
Continuous scale, Per SD in Ln HCY | Â | Â | Â | Â |
 Total Effect (OR) | 0.976(0.911–1.042) | 0.479 | 1.082(0.984–1.179) | 0.100 |
 Natural Direct Effect (OR) | 0.959(0.898–1.020) | 0.191 | 1.042(0.953–1.131) | 0.354 |
 Natural Indirect Effect (OR) | 1.018(0.995–1.040) | 0.125 | 1.038(1.008–1.069) | 0.015 |
 Percentage Mediated (%) | -71.78(-319.92–176.36) | 0.571 | 48.58(-6.03–103.20) | 0.081 |
Binary scale, HHsCRP (vs. Non-HHsCRP) | Â | Â | Â | Â |
 Total Effect (OR) | 1.497(1.218–1.776) | 0.0005 | 1.560(1.210–1.909) | 0.002 |
 Natural Direct Effect (OR) | 1.318(1.085–1.552) | 0.0076 | 1.386(1.090–1.682) | 0.011 |
 Natural Indirect Effect (OR) | 1.136(1.069–1.203) | < 0.001 | 1.125(1.047–1.203) | 0.002 |
 Percentage Mediated (%) | 36.02(18.78–53.25) | < 0.001 | 30.99(13.16–48.83) | 0.001 |
Continuous scale, Per SD in Ln HsCRP | Â | Â | Â | Â |
 Total Effect (OR) | 1.360(1.266–1.455) | < 0.001 | 1.349(1.237–1.461) | < 0.001 |
 Natural Direct Effect (OR) | 1.213(1.132–1.293) | < 0.001 | 1.205(1.109–1.301) | < 0.001 |
 Natural Indirect Effect (OR) | 1.122(1.095–1.149) | < 0.001 | 1.120(1.088–1.152) | < 0.001 |
 Percentage Mediated (%) | 40.93(31.40–50.46) | < 0.001 | 41.34(29.58–53.09) | < 0.001 |