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Fig. 5 | Diabetology & Metabolic Syndrome

Fig. 5

From: Circ-FBXW12 aggravates the development of diabetic nephropathy by binding to miR-31-5p to induce LIN28B

Fig. 5

MiR-31-5p directly targeted LIN28B. A LIN28B contained miR-31-5p binding sites. B and C Dual-luciferase reporter assay and RIP assay were conducted to analyze the interaction between miR-31-5p and LIN28B. D The mRNA level of LIN28B in the serums of DM, DN patients and healthy volunteers was detected by RT-qPCR assay. E The correlation between the levels of mIR-31-5p and LIN28B in DN patients’ serums was analyzed by Spearman’s correlation coefficient analysis. F The protein level of LIN28B in HG-treated HMCs was measured via western blot assay. G The protein level in HG-treated HMCs transfected with miR-NC, miR-31-5p, anti-miR-NC or anti-miR-31-5p was measured through western blot assay. ***P < 0.001, ****P < 0.0001

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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