Time in range, especially overnight time in range, is associated with sudomotor dysfunction in patients with type 1 diabetes

Table 2 CGM glucometrics according to sudomotor function

CGM glucometrics	Total (N = 95)	sudomotor dysfunction (+) group (N = 27)	sudomotor dysfunction (−) group (N = 68)	P value
Whole recorded phase (3 days)
TBR (%)	0.00 (0.00,1.35)	0.00(0.00,0.00)	0.11 (0.00, 2.26)	0.005
TIR (%)	46.41 ± 24.27	36.25 ± 25.08	50.44 ± 22.90	0.009
TAR (%)	49.32 ± 25.85	60.19 ± 26.72	45.00 ± 24.37	0.009
Mean (mmol/L)	10.64 ± 2.60	11.93 ± 3.10	10.13 ± 2.20	0.009
M value (mmol/L)	16.56 (9.20,33.18)	23.70(13.15,59.56)	14.56(8.84, 27.00)	0.024
ADDR	35.17 ± 14.8	41.41 ± 18.55	32.66 ± 12.37	0.030
MAGE (mmol/L)	5.09 ± 2.49	4.95 ± 2.49	5.14 ± 2.51	0.735
SD (mmol/L)	3.62 ± 1.28	3.72 ± 1.15	3.58 ± 1.33	0.636
CV (%)	34.58 ± 11.35	32.06 ± 10.70	35.59 ± 11.53	0.174
Overnight phase (0:00–6:00 am)
TBR (%)	0.00(0.00, 3.33)	0.00(0.00, 0.00)	0.00(0.00, 5.63)	0.013
TIR (%)	64.72(34.17, 88.33)	38.61(2.22, 69.72)	67.64(48.26, 90.35)	0.004
TAR (%)	33.33(5.28, 57.22)	59.72(18.44, 97.98)	29.72(2.85, 47.64)	0.001

Data are presented as means ± SD and median (25% and 75%interquartiles) according to characteristics of distribution. Between-group comparisons were conducted by Student’s t-test and the Mann–Whitney test
TBR, time below range; TIR, time in range; TAR, time above range; Nocturnal TIR was defined as percentage of time blood sugar reached the level of 3.9–10 mmol/L between 00:00 and 6:00 A.M (6 h). Nocturnal TBR was defined as percentage of time blood sugar below the level of 3.9–10 mmol/L between 00:00 and 6:00 A.M (6 h). Nocturnal TAR was defined as percentage of time blood sugar above the level of 3.9–10 mmol/L between 00:00 and 6:00 A.M (6 h)
ADDR average daily risk range, MAGE amplitude of glucose excursions, SD standard deviation, CV coefficient of variation

ISSN: 1758-5996