Fig. 4

Correlation analysis of metabolites and taxons at family levels. The X-axis is the different families of microbiome taxons, the Y-axis is the different metabolites. Asterisks in the boxes represents the significant differences between specific metabolites and microbiome families. Five metabolites (N-methyl-l-glutamic acid, Alloxan, Mercaptopurine, Citric acid and Anabasine) were found significant for o__Coriobacteriales_Unclassified family. Mercaptopurine was significantly different in four families. *P ≤ 0.05, **P ≤ 0.01